张怡

张 怡

教育背景：

清华大学，生命科学学院，博士

工作经历：

2024.2-至今  北京化工大学生命科学与技术学院，副教授

2021.1-2024.1     北京化工大学软物质科学与工程高精尖创新中心，副教授

2018.9-2020.12   北京化工大学软物质科学与工程高精尖创新中心，讲师

主要研究领域：

生化与分子生物学

1. 原核生物免疫系统中关键生物大分子结构与功能的研究

2. 微管翻译后修饰酶结构与功能的研究

获奖及荣誉：

曾获得北京高校第十三届青年教师教学基本功比赛一等奖（第三名）、最佳教案奖、最佳现场展示奖、最佳教学回顾奖；北京化工大学青年教师教学基本功比赛一等奖（第一名）、最受学生欢迎奖；清华大学综合优秀一等奖学金等。

学术成绩：

作为负责人曾主持国家自然科学基金面上项目1项、青年项目1项，北京市自然科学基金青年项目1项，中央高校基本业务费1项，参与国家重点研发计划课题2项。以第一或通讯作者（含共同）身份在《Molecular Cell》、《Nucleic Acids Research》、《Nature Communications》、《Nature Chemical Biology》、《Cell Discovery》、《Journal of Biological Chemistry》等杂志发表高水平论文。

代表性著作：

1. Xueli Cao^#, Bowen Du^#, Fengjiao Han^#, Yu Zhou, Junhui Ren, Wenhe Wang, Zeliang Chen, Yi Zhang*. Crystal Structure of the Chloroplastic Glutamine Phosphoribosylpyrophosphate Amidotransferase GPRAT2 From Arabidopsis thaliana. Frontiers in Plant Science, 2020, 11:157.

   
   

2. Xi Liu^#, Hao Wang#, Jinying Zhu, Yongchao Xie, Xin Liang, Zeliang Chen, Yue Feng*, Yi Zhang*. Structural insights into tubulin detyrosination by vasohibins-SVBP complex. Cell Discovery, 2019, 31:5:65.

   
   

3. Xi Liu^#, Shuliu Dai^#, Yu Zhou^#, Jinyue Liu, Dong Li, Jun Zhang, Yushan Zhu, Qiao Zhao, Yue Feng, Yi Zhang*. Crystal structure of the plant feruloyl–coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates, Biochemical and Biophysical Research Communications, 2022, 594, 8-14.

   
   

4. Junhui Ren^#, Hao Wang^#, Lingguang Yang, Feixue Li, Yao Wu, Zhipu Luo, Zeliang Chen*, Yi Zhang*, Yue Feng*, Structural and mechanistic insights into the inhibition of type IF CRISPR-Cas system by anti-CRISPR protein AcrIF23, 2022, Journal of Biological Chemistry, 298(7), 102124.

   
   

5. Zhengyu Gao^#,Laixing Zhang^#, Zihao Ge^#, Hao Wang, Yourun Yue, Zhuobing Jiang, Xin Wang, Chenying Xu, Yi Zhang*, Maojun Yang*, Yue Feng*, Anti-CRISPR protein AcrIF4 inhibits the type IF CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage, 2022, Journal of Biological Chemistry, 298 (11), 102575.

   
   

6. Xi Liu^#, Laixing Zhang^#, Yu Xiu^#, Teng Gao^#, Ling Huang, Yongchao Xie, Lingguang Yang, Wenhe Wang, Peiyi Wang*, Yi Zhang*, Maojun Yang*, Yue Feng*, Insights into the dual functions of AcrIF14 during the inhibition of type IF CRISPR–Cas surveillance complex, Nucleic Acids Research, 2021, 49 (17), 10178-10191.

   
   

7. Yiying Niu^#, Lingguang Yang^#, Teng Gao^#, Changpeng Dong^#, Buyu Zhang^#, Peipei Yin, Ann-Katrin Hopp, Dongdong Li, Rui Gan, Hongou Wang, Xi Liu, Xueli Cao, Yongchao Xie, Xianbin Meng, Haiteng Deng, Xiaohui Zhang, Jie Ren, Michael O. Hottiger, Zeliang Chen*, Yi Zhang*, Xiaoyun Liu*, Yue Feng*, A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation, Molecular Cell, 2020, 80(3), 512-524.e5.

   
   

8. Yang Wang^#, Yi Zhang^#, Lianwan Chen, Qian Liang, Xiao-Ming Yin, Long Miao, Byung-Ho Kang, Ding Xue*, Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans, 2016, Nature Communications, 7, 12569

   
   

9. Hengwen Yang^#, Yu-Zen Chen^#, Yi Zhang^#, Xiaohui Wang, Xiang Zhao, James I. Godfroy III, Qian Liang, Man Zhang, Tianying Zhang, Quan Yuan, Mary Ann Royal, Monica Driscoll, Ning-Shao Xia, Hang Yin, Ding Xue*,A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells, 2015, Nature Communications,6, 5717

教师寄语:

业精于勤，荒于嬉；形成于思，毁于随。

Nothing is impossible to a willing heart.

招生要求：

善于沟通与学习，积极努力。