宋立华

发布时间：2024-03-01

姓名：宋立华

职称：北京化工大学副教授，北京市微生物学专业研究员（正高级）

邮箱：songlihua@mail.buct.edu.cn

办公地址：西校区教学楼415B


教育背景：

2001.8 – 2006.6，军事医学科学院，博士（军事预防医学专业）

1997.9 – 2001.7，山东大学，学士（微生物学专业）

工作经历：

2010.07 – 2013.06，美国NIH/NIAID/RML，博士后

2009.07 – 2018.07，北京微生物流行病研究所，副研究员

2013.09 – 2017.12，北京微生物流行病研究所，立克次体室主任

2019.01 – 至今，北京化工大学生命科学与技术学院，副教授

2023.11 – 至今，北京市微生物学专业研究员（正高级）

学术兼职：

  1. 中国人兽共患病学报编委

  2. BMC Microbiology编委

  3. Discover Viruses编委

  4. Frontiers in microbiology和Frontiers in immunology等杂志reviewer editor

  5. PLOS Pathogens、mBio等杂志审稿人

  6. 中国人兽共患病学会衣原体学组副组长

  7. 中国衣原体学会学术委员

  8. 国家自然科学基金函审专家

主要研究领域：

重要病原微生物的防治技术与致病机制。重点关注新发突发病毒病、专性胞内寄生菌和多重耐药菌等。采用生物化学、生物信息学、合成生物学等多学科方法，开展传染病防控新技术新方法研究。目前的主要研究方向有: 1.病原体快速检测技术；2.重要胞内菌和病毒病的药物和疫苗。

获奖及荣誉：

  1. 2016年，高致病性病原微生物检测鉴定新技术和装备，国家科技进步二等奖，排名第七

  2. 2015年，呼吸道、肠道新发病毒性传染病病原体及防控技术研究，军队医疗成果一等奖，排名第二

  3. 2013年，鹦鹉热衣原体基因工程疫苗及快速检测试剂，国家技术发明二等奖，排名第三

  4. 2011年，禽畜鹦鹉热衣原体基因工程亚单位疫苗和检测技术的研究，北京市科技进步一等奖，排名第三

科研项目：

  1. 国家自然科学基金国际合作研究项目、3211101856、反刍动物重要新发再发传染病的分子病原学和诊断技术研究、2022/01-2024/12、260万元、主持。

  2. 国家自然科学基金国际合作项目、3191101002、布鲁氏菌致反刍动物流产的风险因素与作用机制研究、2020/01-2022/12、59.43万元、主持。

  3. 内蒙古自治区科技重大专项项目、2019ZD006、人畜间布病综合防控技术集成与示范、2019.11-2022.10、90万元、主持。

  4. 北京市科技重大专项项目、Z171100000417015、沙眼衣原体减毒活疫苗候选株的研制、2017/03-2019/02、100万元、主持。

  5. 国家自然科学基金面上项目、31570177、沙眼衣原体质粒编码毒力因子Pgp4的致病机理研究、2016/01-2019/12、72.9万元、主持。

  6. 国家自然科学基金面上项目、81071360、新型呼肠病毒细胞吸附蛋白致病机理的研究、2011/01-2013/12、30万元、主持。

  7. 国家自然科学基金青年科学基金项目、30500369、流产嗜衣原体媒介传播机制的探索研究、2006/01-2008/12、25万元、主持。

代表性著作：

  1. Lai Wei1#, Shuiqing Liu#, Shanshan Lu#, Shengdong Luo, Xiaoping An, Huahao Fan, Erguang Li*, Lihua Song*. An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR). mLife, 2024. DOI:10.1002/mlf2.12122.

  2. Shanshan Lu#, Shengdong Luo#, Bingke Bai, Zhenping Fan, Bixia Hong, Wen Xu, Hongbin Ma, Weiwei Chen, Huahao Fan*, Yigang Tong*, Lihua Song*. Omicron breakthrough infections in wild-type SARS-CoV-2 vaccinees elicit high levels of neutralizing antibodies against pangolin coronavirus GX_P2V. Journal of Medical Virology, 2023, 95(8): e29031.

  3. Shanshan Lu, Shengdong Luo, Chang Liu, Muli Li, Xiaoping An, Mengzhe Li, Jun Hou, Huahao Fan∗, Panyong Mao∗, Yigang Tong∗, Lihua Song∗. Induction of significant neutralizing antibodies against SARS-CoV-2 by a highly attenuated pangolin coronavirus variant with a 104nt deletion at the 3'-UTR. Emerging Microbes & Infections, 2023, 12(1): 2151383.

  4. Ailan Xu#, Bixia Hong#, Fuxing Lou#, ShuqiWang#, Wenye Li, Amna Shafqat, Xiaoping An, Yunwei Zhao∗,Lihua Song∗, Yigang Tong∗, Huahao Fan∗. Sub-lineages of the SARS-CoV-2 Omicron variants: Characteristics and prevention. MedComm (2020), 2022, 3(3): e172.

  5. Zehan Pang#, Ruolan Hu#, Lili Tian#, Fuxing Lou#, Yangzhen Chen#, Shuqi Wang, Shiting He, Shaozhou Zhu, Xiaoping An, Lihua Song*, Feitong Liu*, Yigang Tong*, Huahao Fan*. Overview of Breastfeeding Under COVID-19 Pandemic. Front Immunol, 2022, 13: 896068.

  6. Maochen Li, Han Wang, Lili Tian, Zehan Pang, Qingkun Yang, Tianqi Huang, Junfen Fan*, Lihua Song*, Yigang Tong*, Huahao Fan*. COVID-19 vaccine development: milestones, lessons, and prospects. Signal Transduction and Targeted Therapy, 2022, 7(1): 146. doi: 10.1038/s41392-022-00996-y.

  7. Ke Han, Yinuo Zhu, Fei Li, Mengzhe Li, Xiaoping An, Lihua Song*, Huahao Fan*, Yigang Tong*. Genomic Analysis of Bacteriophage BUCT86 Infecting Klebsiella Pneumoniae. Microbiol Resour Announc, 2022: e0123821.

  8. Rujia Chen, Xuling Xu, Pengjun Han, Yunjia Hu, Hongbo Qin, Mengzhe Li, Xiaoping An, Lihua Song*, Huahao Fan*, Yigang Tong*. Complete Genome Sequence of Aeromonas hydrophila Bacteriophage BUCT552. Microbiol Resour Announc, 2022, 11(2): e0117221.

  9. Lili Tian#, Zehan Pang#, Maochen Li#, Fuxing Lou#, Xiaoping An, Shaozhou Zhu, Lihua Song*, Yigang Tong*, Huahao Fan*, Junfen Fan*. Molnupiravir and Its Antiviral Activity Against COVID-19. Frontiers in Immunology, 2022,13: 855496.

  10. Fuxing Lou#, Hongbo Qin#, Shiting He#, Maochen Li#, Xiaoping An, Lihua Song*, Yigang Tong*, Huahao Fan*. The benefits of breastfeeding still outweigh the risks of COVID-19 transmission, Frontiers in Medicine, 2021, 8: 703950.

  11. Shengdong Luo#, Shanshan Lu#, Huahao Fan#, Zeliang Chen#, Zhihui Sun, Yan Hu, Ruisheng Li, Xiaoping An, Vladimir N Uversky, Yigang Tong*, Lihua Song*. The Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages, Journal of Bacteriology, 2021, 203(9): e00588-20.

  12. Yunjia Hu#, Meiqin Liu#, Hongbo Qin#, Haofeng Lin, Xiaoping An, Zhengli Shi, Lihua Song*, Xinglou Yang*, Huahao Fan*, Yigang Tong*. Artemether, artesunate, arteannuin B, echinatin, licochalcone B and andrographolide effectively inhibit SARS-CoV-2 and related viruses in vitro. Frontiers in Cellular and Infection Microbiology, 2021, 11: 680127.

  13. Pengjun Han, Yunjia Hu, Xiaoping An, Lihua Song*, Huahao Fan*, Yigang Tong*. Biochemical and genomic characterization of a novel bacteriophage BUCT555 lysing Stenotrophomonas maltophilia. Virus Research, 2021, 301: 198465.

  14. Yunjia Hu#, Shanwei Tong#, Ping Li#, Xiaoping An, Lihua Song*, Huahao Fan*, Yigang Tong*. Characterization and genome sequence of the genetically unique Escherichia bacteriophage vB_EcoM_IME392. Archives of Virology, 2021, 166: 2505-2520. doi: 10.1007/s00705-021-05160-5.

  15. Huahao Fan, Liqin Wang, Wenli Liu, Xiaoping An, Zhendong Liu, Xiaoqi He, Lihua Song*, and Yigang Tong*. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Chinese Medical Journal (English), 2020, 133(9): 1051-1056.

  16. Tao Wang, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou and Lihua Song. Lipid A has significance for optimal growth of Coxiella burnetii in macrophage-like THP-1 cells and to a lesser extent in axenic media and non-phagocytic cells. Frontiers in Cellular and Infection Microbiology, 2018, 8: 192. doi: 10.3389/fcimb.2018.00192

  17. Gail L. Sturdevant, Claire E. Couch, Heather S. Watkins, Linnell B. Randall, Jillian M. Ilgenfritz, Lihua Song, Timothy R. Southern, William M. Whitmire, Harlan D. Caldwell, Laszlo Kari. The developmentally regulated Chlamydia trachomatis gene chxR is not essential for in vitro or in vivo growth. Pathogens and Disease, 2017, 75(3).

  18. 鲁辛辛, 冯乐, 于永慧, 罗声栋, 孙志会, 王涛, 端青, 王宁利, 宋立华. 青海藏区B型沙眼衣原体的分离培养与鉴定. 微生物学通报, 2017, 44(6): 1444-1450.

  19. 于永慧, 王涛, 罗声栋, 冯乐, 孙志会, 宋立华. Q热性心内膜炎1例抗I相和II相抗原IgG抗体的跟踪检测报道. 军事医学, 2017, 41(2): 160-161.

  20. Le Feng, Xinxin Lu, Yonghui Yu, Tao Wang, Shengdong Luo, Zhihui Sun, Qing, Duan, Ningli Wang, Lihua Song. Survey, Culture, and Genome Analysis of Ocular Chlamydia trachomatis in Tibetan Boarding Primary Schools in Qinghai Province, China. Frontiers in Cellular and Infection Microbiology, 2017, 6: 207. doi: 10.3389/fcimb.2016.00207.

  21. Yongfeng Lu, Jun He, Tingting Zuo, Yanwei Li, Hong Zhu, Qing Duan, Lihua Song. Phylogeography of Francisella tularensis from Tibet, China: Evidence for an Asian Origin and Radiation of Holarctica-Type Tularemia. Ticks Tick Borne Dis, 2016, 7(5): 865-868.

  22. Chunfu Yang, Tregei Starr, Lihua Song, John H. Carlson, Gail L. Sturdevant, Paul A. Beare, William M. Whitmire, Harlan D. Caldwell. Chlamydial lytic exit from host cells is plasmid regulated. mBio, 2015, 6(6): e01648-15. doi:10.1128/mBio.01648-15.

  23. Stephen F. Porcel, John H. Carlson, Daniel E. Sturdevant, Gail L. Sturdevant, Kishore Kanakabandi, Kimmo Virtaneva, Hannah Wilder, William M. Whitmire, Lihua Song, Harlan D. Caldwell. Transcriptional Profiling of Human Epithelial Cells Infected with Plasmid-Bearing and Plasmid-Deficient Chlamydia trachomatis. Infection and Immunity, 2015, 83(2): 534-543.

  24. 王涛, 宋立华. 贝氏柯克斯体的分子致病机理究进展. 中国人兽共患病学报, 2015, 31(9): 876-880, 885.

  25. Gail L. Sturdevant, John H. Carlson, William M. Whitmire, Bing Zhou, Lihua Song, and Harlan D. Caldwell. Infectivity of urogenital Chlamydia trachomatis plasmid-deficient, CT135-null, and double-deficient strains in female mice [J]. Pathogens and Disease, 2014, 71(1): 90-92.

  26. Lihua Song, John H. Carlson, Bing Zhou, Kimmo Virtaneva, William M. Whitmire, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty, and Harlan D. Caldwell. Plasmid-mediated transformation tropism of chlamydial biovars [J]. Pathogens and Disease, 2014, 70(2): 189-193.

  27. 李鹏, 端青, 宋立华. 衣原体最新分类体系与分类鉴定方法研究进展. 中国人兽共患病学报, 2014, 30(12): 1262-1266.

  28. Lihua Song, John H. Carlson, William M. Whitmire, Laszlo Kari, Kimmo Virtaneva, Daniel E. Sturdevant, Heather Watkins, Bing Zhou, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty, and Harlan D. Caldwell. Chlamydia trachomatis Plasmid-Encoded Pgp4 Is a Transcriptional Regulator of Virulence-Associated Genes [J]. Infection and Immunity, 2013, 81(3): 636-44. (commented)

  29. Lihua Song, Yan Li, Guangqiao Liu, Jun He, Hong Zhu, and Qing Duan. Genotyping of Chlamydophila psittaci strains derived from avian and mammalian species [J]. Vet Res Commun, 2009, 33: 577-580.

  30. Lihua Song, Bing Zhou, Hong Zhu, and Qing Duan. Outdoor electric mosquito killing apparatuses for malaria control in a hyperendemic area [J]. Clinical Infectious Diseases, 2009, 49: 480.



教师寄语:

宝剑锋从磨砺出，梅花香自苦寒来。


招生要求：

认真刻苦、热爱科研、执行力强、能阅读英文文献