范华昊

发布时间:2020-03-07



姓名:范华昊


职称:副教授


座机:010-64451781       

                             

邮箱:fanhuahao.1987@163.com





教育背景:

2016年7月毕业于北京大学病原生物学专业,获理学博士学位。


工作经历:

2019.11-至今         北京化工大学生命科学与技术学院,副教授

2017.08-2019.10    清华大学医学院,博士后

2016.07-2017.07    北京302医院青少年肝病诊疗中心,助理研究员


主要研究领域:

研究方向一:新发传染病(冠状病毒、肠道病毒)药物筛选及病毒感染宿主分子机制研究

研究方向二:噬菌体基础与临床


获奖及荣誉:

2020年北京化工大学校长奖“科技抗疫团队奖”,排名第二

2020年度北京化工大学“重要科技进展”,排名第二


学术兼职:

中国医药生物技术协会单克隆抗体专业委员会委员;

北京医学会微生物与免疫学分会青年委员;

Exploration杂志青年编委;

Molecules专刊主编;

Frontiers in Bioscience-Landmark专刊主编;

Signal Transduction and Targeted Therapy、Briefings in Bioinformatics、Emerging Microbes & Infections、Journal of Infection、Frontiers in Immunology、Journa of Medical Virology、Expert Review of Anti-infective Therapy等期刊审稿人。


目前从事的主要研究工作介绍:

本人主要研究方向为抗病毒药物筛选、免疫逃逸及病毒宿主互作机制研究,紧跟领域国际学术前沿,结合学科发展趋势,提炼关键科学问题,开展了系统深入的研究工作,主要研究方向包括:

(1)千金藤素抗新冠病毒的发现与机制研究;

(2)母乳抗新冠病毒的发现与机制研究;

(3)“三药三方”为代表的中药方剂抗新冠病毒的作用机制研究;

(4)等离子体广谱高效消杀冠状病毒研究;

(5)肝炎病毒 HCV 吸附受体在胞间传递中的重要作用及 HEV 危险因素分析;

(6)新冠患者的临床特征分析与新冠病毒变异特征、抗病毒药物最新进展系列综述:

(7)噬菌体基础与临床应用


承担项目:

1.     JW科技委后勤开放项目,RNA病毒感染与传播的动物模型研究课题负责人在研

2.     合生元(广州)健康产品有限公司,乳源活性成分抗类新冠病毒GX_P2V、肠道病毒EV71与轮状病毒的效果评价课题负责人在研

3.     JD生物安全项目,新冠病毒演化模拟变体功能学验证研究,课题负责人在研

4.     JD生物安全项目,千金藤素抗SARS-CoV-2病毒的机制研究课题负责人在研

5.     国家自然科学基金委员会青年项目,乳铁蛋白通过靶向S蛋白/RdRp和调节免疫信号通路广谱抑制冠状病毒作用机制研究课题负责人在研

6.     国家科学技术部重点研发计划项目,DNA存储中的组合方法课题骨干在研

7.     国家自然科学基金委员会原创项目,千金藤素抗新冠病毒作用机制研究课题骨干在研

8.     “国家中医药创新团队-新冠揭榜”项目骨干在研

9.     科技部“十三五”重大专项应急项目“中医药疗法应对Delta变异病毒”项目骨干在研

10.  军事医学研究院,细胞模型体外(In vitro)抗新型冠状病毒药物测试课题负责人在研

11.  中关村国际医药检验认证科技有限公司,点而康表面湿巾抗HCV病毒效果评价课题负责人在研

12.  国家卫生计生委国家科技重大专项,登革病毒及寨卡病毒动物-人-动物跨物种传播机制课题骨干已结题

13.  北京市教委,北京高校新冠环境样本检测课题骨干已结题

14.  中央高校基本业务费自由探索项目,新型高致病性犬冠状病毒的进化与致病机制研究课题负责人已结题

15.  北京诺安百汇医药科技有限公司,噬菌体技术服务课题骨干已结题

16.  上海微谱化工技术服务有限公司,冠状病毒灭活检测课题骨干已结题

17.  国家重点研发计划,2019-nCoV溯源和传播传播途径研究已结题

18.  中国博士后科学基金会面上项目,亚感染剂量寨卡病毒增强病毒对埃及伊蚊再次感染课题负责人已结题


发表文章(一作和通讯作者):

主要从事新冠病毒科研攻关和噬菌体基础临床应用。以第一作者和通讯作者发表SCI论文40余篇,其中影响因子20分以上8篇,相关期刊主要包括The Lancet Microbe(1篇,中科院Top期刊,IF=86.2)、Signal Transduction and Targeted Therapy(5篇,中科院Top期刊,IF=38.1)、Clinical Infectious Diseases(1篇,中科院Top期刊,IF=20.99)、Journal of Medical Virology(1篇,IF=20.8)、Journal of Hazardous Materials(1篇,中科院Top期刊,IF=14.2)、Briefings in Bioinformatics(2篇,中科院Top期刊,IF=13.99)、Frontiers in Immunology(3篇,中科院Top期刊,IF=8.8)、Journal of Virology(4篇,中科院Top期刊,IF=6.5)等,授权专利8项,获得2020年北京化工大学校长奖“科技抗疫团队奖”(排名第二)、2020年度北京化工大学重要科技进展(排名第二)、2020年北京化工大学生命科学与技术学院高水平论文奖(排名第一)。

[1] Huahao Fan*, Liqin Wang*, Wenli Liu*, Xiaoping An*, Zhendong Liu, Xiaoqi He, Lihua Song#,Yigang Tong#. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Chinese Medical Journal 2020; 133(9):1051-1056. JCR IF:6.1; ESI highly cited paper(被引大于200次); First author 研究论文

[2] Huahao Fan#,*, Fuxing Lou#, Junfen Fan#, Maochen Li#, Yigang Tong*. The emergence of powerful oral anti-COVID-19 drugs in the post-vaccine era. The Lancet Microbe. 2022; 3(2):e91. JCR IF:86.2; First author and co-corresponding author 评论文章

[3] Maochen Li*, Han Wang*, Lili Tian*, Zehan Pang*, Qingkun Yang, Tianqi Huang, Junfen Fan, Lihua Song#, Yigang Tong#, Huahao Fan#. COVID-19 vaccine development: milestones, lessons, and prospects. Signal Transduction and Targeted Therapy. 2022; 7(1):146. JCR IF:38.1; Top journal; Corresponding author 长篇综述

[4] Maochen Li*, Fuxing Lou*, Huahao Fan#. SARS-CoV-2 variant Omicron: currently the most complete “escapee” from neutralization by antibodies and vaccines. Signal Transduction and Targeted Therapy. 2022;7(1):28. JCR IF:38.1; Top journal; Corresponding author评论文章

[5] Maochen Li*, Fuxing Lou*, Huahao Fan#. SARS-CoV-2 Variants of Concern Delta: a great challenge to prevention and control of COVID-19. Signal Transduction and Targeted Therapy. 2021; 6(1): 349. JCR IF:38.1; Top journal; Corresponding author 评论文章

[6] Maochen Li*, Fuxing Lou*, Huahao Fan#. SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency. Signal Transduction and Targeted Therapy. 2021; 6(1):151. JCR IF:38.1; Top journal; Corresponding author 评论文章

[7] Huahao Fan*, Bixia Hong*, Yuqian Luo*, Qi Peng*, Liqin Wang, Xiangshu Jin, Yangzhen Chen, Yunjia Hu, Yi Shi, Tong Li, Hui Zhuang, Yi-Hua Zhou#, Yigang Tong#, Kuanhui Xiang#. The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro. Signal Transduction and Targeted Therapy. 2020; 5(1):275. JCR IF:38.1; Top journal; First author 封面文章研究论文

[8] Lijun Sun*, Lijun Shen*, Junfen Fan*, Fengjun Gu, Mei Hu, Yiran An, Qing Zhou, Huahao Fan#, Jingfeng Bi#. Clinical features of patients with coronavirus disease 2019 from a designated hospital in Beijing, China. Journal of Medical Virology. 2020; 92(10):2055-2066. JCR IF:20.7; Co-corresponding author 临床研究论文

[9] Lijun Sun*, Junfen Fan*, Huiru Gao, Liying Shan, Xue Li, Hui Zhuang, and Huahao Fan#. Background End-stage Liver Diseases but not Pure HBV Infection Exacerbate Clinical Outcomes in Patients with Acute Hepatitis E. Clinical infectious diseases 2020; 70(12):2747-2748. JCR IF:20.99; Top journal; Corresponding author临床研究论文

[10] Hongbo Qin*, Hengju Qiu*, Shi-Ting He*, Bixia Hong*, Ke Liu*, Fuxing Lou, Maochen Li, Pan Hu, Xianghao Kong, Yujie Song, Yuchen Liu, Mingfang Pu, Pengjun Han, Mengzhe Li, Xiaoping An, Lihua Song, Yigang Tong#, Huahao Fan#, Ruixue Wang#. Efficient disinfection of SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage. Journal of Hazardous Materials. 2022; 430:128414. JCR IF:14.2; Top journal; Corresponding author 研究论文

[11] Shasha Li*, Wenli Liu*, Yangzhen Chen*, Liqin Wang*, Wenlin An, Xiaoping An, Lihua Song, Yigang Tong#, Huahao Fan#, Chenyang Lu#. Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus. Briefings in Bioinformatics. 2021; 22(2):1378-1386. JCR IF:13.99; Top journal; Co-corresponding author 研究论文

[12] Pengfei Pei*, Hongbo Qin*, Jialin Chen, Fengli Wang, Chengzhi He, Shiting He, Bixia Hong, Ke Liu, Ren-zhong Qiao, Huahao Fan#, Yi-gang Tong#, Long Chen#, Shi-Zhong Luo#. Computational Design of Ultrashort Peptide Inhibitors of the Receptor Binding Domain (RBD) of the SARS-CoV-2 S protein. Briefings in Bioinformatics. 2021; 22(6):bbab243. JCR IF:13.99; Top journal; Co-corresponding author研究论文

[13] Huahao Fan*,#, Shi-Ting He*, Pengjun Han*, Bixia Hong*, Ke Liu*, Maochen Li*, Shuqi Wang*, Yigang Tong#. Cepharanthine: A Promising Old Drug against SARS-CoV-2. Advanced Biology. 2022; doi: 10.1002/adbi.202200148. JCR IF:4.6; Co-corresponding author 评论文章

[14] 范华昊*,#,刘珂*,洪碧霞*,何诗婷*,韩鹏军*,李卯晨*,王姝琦*,童贻刚#.千金藤素抗新冠病毒研究进展.南方医科大学学报 2022, 42(6): 955-956 评论文章

[15]Lili Tian*, Zehan Pang*, Maochen Li*, Fuxing Lou*, Xiaoping An, Shaozhou Zhu, Lihua Song#, Yigang Tong#Huahao Fan#, Junfen Fan#. Molnupiravir and Its Antiviral Activity Against COVID-19. Frontiers in Immunology. 2022; 13:855496. JCR IF:8.8; Corresponding author 长篇综述

[16] Zehan Pang*, Ruolan Hu*, Lili Tian*, Fuxing Lou*, Yangzhen Chen, Shuqi Wang, Shiting He, Shaozhou Zhu, Xiaoping An, Lihua Song#, Feitong Liu#, Yigang Tong#, Huahao Fan#. Overview of breastfeeding under COVID-19 pandemic. Frontiers in Immunology. 2022; 13:896068. JCR IF:8.8; Corresponding author 长篇综述

[17] Mingfang Pu*, Pengjun Han*, Guangye Zhang, Yucong Liu, Yahao Li, Fei Li, Mengzhe Li, Xiaoping An, Lihua Song, Yiming Chen, Huahao Fan#, Yigang Tong#. Characterization and Comparative Genomics Analysis of a New Bacteriophage BUCT610 against Klebsiella pneumoniae and Efficacy Assessment in Galleria mellonella Larvae. International Journal of Molecular Sciences. 2022; 23(14):8040. JCR IF:6.2; Corresponding author 研究论文

[18] Pengjun Han, Wenjing Zhang, Mingfang Pu, Yahao Li, Lihua Song, Xiaoping An, Mengzhe Li, Fei Li, Shuyan Zhang#, Huahao Fan#, Yigang Tong#. Characterization of the Bacteriophage BUCT603 and Therapeutic Potential Evaluation Against Drug-Resistant Stenotrophomonas maltophilia in a Mouse Model. Frontiers in Microbiology. 2022; 13:906961. JCR IF:6.1; Co-corresponding author 研究论文

[19] Mingfang Pu*, Yahao Li*, Pengjun Han, Wei Lin, Ronghua Geng, Fen Qu, Xiaoping An, Lihua Song, Yigang Tong, Shuyan Zhang#, Zhen Cai#, Huahao Fan#. Genomic characterization of a new phage BUCT541 against Klebsiella pneumoniae K1-ST23 and efficacy assessment in mouse and Galleria mellonella larvae. Frontiers in Microbiology. 2022; doi: 10.3389/fmicb.2022.950737 JCR IF:6.1; Co-corresponding author 研究论文

[20] Ailan Xu*, Bixia Hong*, Fuxing Lou*, Shuqi Wang*, Wenye Li, Amna Shafqat, Xiaoping An, Yunwei Zhao, Lihua Song, Yigang Tong, Huahao Fan. Sub-lineages of the SARS-CoV-2 Omicron Variants: Characteristics and Prevention. Medcomm.2022; doi: 10.1002/mco2.172 JCR; Co-corresponding author 研究论文

[21] Fuxing Lou*, Maochen Li*#, Zehan Pang*, Lin Jiang*, Lin Guan*, Lili Tian, Jiaming Hu, Junfen Fan#, Huahao Fan#. Understanding the secret of SARS-CoV-2 variants of interest/concern and immune escape. Frontiers in Immunology. 2021; 12:744242. JCR IF:8.8; Corresponding author 长篇综述

[22] Yahao Li, Pengjun Han, Mingfang Pu, Fei Li, Mengzhe Li, Xiaoping An, Lihua Song, Huahao Fan#, Yigang Tong#, Zeliang Chen#. Genomic Analysis of the Serratia marcescens Bacteriophage BUCT660. Microbiology Resource Announcements. 2022; doi: 10.1128/mra.00406-22. 基因组报告

[23] Hunjia Hu*, Meiqin Liu*, Hongbo Qin*, Haofeng Lin, Xiaoping An, Zhengli Shi, Lihua Song#, Xinglou Yang#, Huahao Fan#, Yigang Tong#. Artemether, artesunate, arteannuin B, echinatin, licochalcone B and andrographolide effectively inhibit SARS-CoV-2 and related viruses in vitro. Frontiers in Cellular and Infection Microbiology. 2021 doi: 10.3389/fcimb.2021.680127. JCR IF:6.1; Co-corresponding author 研究论文

[24] Huahao Fan*,#, Junfen Fan*, Suming Chen, Yangzhen Chen, Huiru Gao, Liying Shan Xue Li, Fengjun Gu, Hui Zhuang#, Lijun Sun#. Prognostic Significance of End-stage Liver Diseases, Respiratory Tract Infection and Chronic Kidney Diseases in Symptomatic Acute Hepatitis E. Frontiers in Cellular and Infection Microbiology. 2021; 10:593674. JCR IF:6.1; First author and co-corresponding author 研究论文

[25] Huahao Fan*, Luhua Qiao*, Kyung-Don Kang, Junfen Fan, Wensheng Wei, and Guangxiang Luo. Attachment and post-attachment receptors important for hepatitis C virus infection and cell-to-cell transmission. Journal of Virology 2017; 91(13):e00280-17. JCR IF:6.5; Top Journal; Co-first author 研究论文

[26] Pengjun Han, Yunjia Hu, Xiaoping An, Lihua Song#, Huahao Fan#, Yigang Tong#. Biochemical and genomic characterization of a novel bacteriophage BUCT555 lysing Stenotrophomonas maltophilia. Virus Research. 2021; 301:198465. JCR IF:6.3; Co-corresponding author 研究论文

[27] Pengjun Han, Wenjing Zhang, Mingfang Pu, Yahao Li, Lihua Song, Xiaoping An, Mengzhe Li, Fei Li, Shuyan Zhang*, Huahao Fan* and Yigang Tong*. Characterization of the Bacteriophage BUCT603 and Therapeutic Potential Evaluation Against Drug-Resistant Stenotrophomonas maltophilia in a Mouse Model. Frontiers in Microbiology. 2022; doi: 10.3389/fmicb.2022.906961. JCR IF:6.1; Co-corresponding author 研究论文

[28] Mingfang Pu*, Yahao Li*, Pengjun Han, Wei Lin, Yigang Tong, Zhen Cai#, Shuyan Zhang#, Huahao Fan#. Genomic characterization of a new phage BUCT541 against Klebsiella pneumonia ST275 and efficacy assessment in mouse and Galleria mellonella larvae. Frontiers in Microbiology. 2022; Accepted. JCR IF:6.1; Co-corresponding author 研究论文

[29] Zhen Cai, Tianye Jia, Mingfang Pu, Shuyong Zhang, Jingxia Zhang, Ronghua Geng, Suming Chen, Yahao Li, Huahao Fan*, Yigang Tong*, Fen Qu*. Clinical and Molecular Analysis of ST11-K47 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae: A Strain Causing Liver Abscess. Pathogens. 2022; 11(6):657. JCR IF:4.5; Co-corresponding author 研究论文

[30] Huahao Fan#,*, Shi-ting He#, Pengjun Han#, Bixia Hong#, Ke Liu#, Maochen Li#, Shuqi Wang#, and Yigang Tong*. Cepharanthine: A Promising Old Drug against SARS-CoV-2.Advanced Biology. 2022. doi: 10.1002/adbi.202200148. First author and co-corresponding author 研究论文

[31] Fuxing Lou*, Hongbo Qin*, Shiting He*, Xiaoping An, Lihua Song#, Yigang Tong#, Huahao Fan#. The benefits of breastfeeding still outweigh the risks of COVID-19 transmission. Frontiers in Medicine. 2021; 8:703950. JCR IF:5.1; Corresponding author 长篇综述

[32] Yinuo Zhu, Ke Han, Long Chen#, Shizhong Luo#, Huahao Fan#, Yigang Tong#. Biological characterization and genomic analysis of Acinetobacter baumannii phage BUCT628. Archives of Virology. 2022 Apr 19. doi: 10.1007/s00705-022-05425-7. JCR IF:2.7; Co-corresponding author 研究论文

[33] Ke Han, Yinuo Zhu, Fei Li, Mengzhe Li, Xiaoping An, Lihua Song#, Huahao Fan#, Yigang Tong#. Genomic analysis of Acinetobacter phage BUCT629, a newly isolated member of the genus Obolenskvirus. Archives of Virology. 2022; 167(4):1197-1199. JCR IF:2.7; Co-corresponding author 研究论文

[34] Ke Han, Yinuo Zhu, Fei Li, Mengzhe Li, Xiaoping An, Lihua Song#, Huahao Fan#, Yigang Tong#. Genomic Analysis of Bacteriophage BUCT86 Infecting Klebsiella Pneumoniae. Microbiology Resource Announcement. 2022 Apr 11;e0123821. JCR IF:0.8; Co-corresponding author 基因组报告

[35] Rujia Chen, Xuling Xu, Pengjun Han, Yunjia Hu, Hongbo Qin, Mengzhe Li, Xiaoping An, Lihua Song#, Huahao Fan#, Yigang Tong#. Complete Genome Sequence of Aeromonas hydrophila Bacteriophage BUCT552. Microbiology Resource Announcement. 2022 Feb 17;11(2):e0117221. JCR IF:0.8; Co-corresponding author 基因组报告

[36] Yunjia Hu*, Shanwei Tong*, Ping Li*, Xiaoping An, Lihua Song#, Xinglou Yang#, Huahao Fan#, Yigang Tong#. Characterization and Genome Sequence of a Genetically Unique Escherichia bacteriophage vB_EcoM_IME392. Archives of Virology. 2021; 166(9):2505-2520. JCR IF:2.7; Co-corresponding author 研究论文

[37] Shengdong Luo*, Shanshan Lu*, Huahao Fan*, Zhihui Sun, Yan Hu, Ruisheng Li, Xiaoping An, Vladimir N Uversky, Zeliang Chen#, Yigang Tong#, Lihua Song#. he Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages. Journal of Bacteriology. 2021; 203(9):e00588-20. JCR IF:3.5; Co-first author 研究论文

[38] Huan Zhang*, Huanying Zheng*, Jinying Zhu*, Qiao Dong*, Jin Wang*, Huahao Fan*, Yangzhen Chen*, Xi Zhang, Xiaohu Han, Qianlin Li, Jiahai Lu#, Yigang Tong#, Zeliang Chen#. The Ubiquitin-modified Proteome of SARS-CoV-2-infected Host Cells Reveals Insights into Virus-Host Interaction and Pathogenesis. Journal of Proteome Research. 2021; 20(5):2224-2239. JCR IF:5.4; Co-first author 研究论文

[39] Wenjing Zhang*, Rongrong Zhang*, Yunjia Hu*, Yujie Liu, Liqin Wang, Xiaoping An, Lihua Song, Taoxing Shi#, Huahao Fan#,Yigang Tong#, Hui Liu#. Biological characteristics and genomic analysis of a Stenotrophomonas maltophilia phage vB_SmaS_BUCT548. Virus Genes. 2021; 57(2):205-216. JCR IF:2.2; Co-corresponding author研究论文

[40] Chen Chen*, Huahao Fan*, Yong Huang, Fan Peng, Hang Fan, Shoujun Yuan#, and Yigang Tong#. Recombinant lysostaphin protects mice from methicillin-resistant Staphylococcus aureus pneumonia. Biomed Research International 2014; 602185. JCR IF:3.2; Co-first author研究论文

[41] Huahao Fan*, Hang Fan*, Xiaoping An*, Yong Huang, Zhiyi Zhang, Zhiqiang Mi#, and Yigang Tong#. Complete genome sequence of IME11, a new N4-like bacteriophage. Journal of Virology 2012; 86:13861. JCR IF:6.5; Top Journal; Co-first author 基因组报告

[42] Huahao Fan*, Yong Huang*, Zhiqiang Mi*, Xiuyun Yin, Lin Wang, Hang Fan, Zhiyi Zhang, Xiaoping An, Jiankui Chen#, and Yigang Tong#. Complete genome sequence of IME13, a Stenotrophomonas maltophilia bacteriophage with large burst size and unique plaque polymorphism. Journal of Virology 2012; 86:11392-11393. JCR IF:6.5; Top Journal; Co-first author 基因组报告

[43] Yong Huang*, Huahao Fan*, Guangqian Pei, Hang Fan, Zhiyi Zhang, Xiaoping An, Zhiqiang Mi, Taoxing Shi#, Yigang Tong#. Complete genome sequence of IME15, the first T7-like bacteriophage lytic to pan-antibiotic-resistant Stenotrophomonas maltophilia. Journal of Virology 86: 13839–13840. JCR IF:6.5; Top Journal; Co-first author 基因组报告


授权专利:

1.     穿山甲冠状病毒xCoV及其应用和药物抗冠状病毒感染的应用 202110172158.7(排名:2)

2.     蒿甲醚在治疗和预防柯萨奇病毒感染中的应用     ZL202011286678.2(排名:1)

3.     霉酚酸在治疗和预防柯萨奇病毒感染中的应用     ZL202011284669.X(排名:1)

4.     C26H18O4在治疗和预防柯萨奇病毒感染中的应用     ZL202011286665.5(排名:2)

5.     一种HCBP6基因敲除细胞系及其构建方法    ZL201810052325.2(排名:2)

6.     一种从胚胎干细胞分化获得肺上皮细胞的方法及其使用的培养基ZL 202110037419.4 (排名:2)

7.     替拉曲考在治疗和预防柯萨奇病毒感染中的应用ZL202011284668.2   (排名:3)

8.     一种治疗冠状病毒感染的中药     ZL202010234228.2   (排名:4)

9.     一种简易式核酸提取装置      ZL202121131312.8   (排名:4)



教师寄语:

天道酬勤,向善向上。


招生要求:

诚实守信,做人靠谱,团结同学,尊敬师长,对课题组从事的课题确实有兴趣。