| 姓名：李超
职称：副教授
办公地址：科技大厦西配楼414 |
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教育背景：
2007.9-2010.6 北京化工大学 生命学院，博士 （化学工程与技术专业）
2004.9-2007.6 北京化工大学 生命学院，硕士 （制药工程专业）
2000.9-2004.6 北京化工大学 化工学院，学士（生物工程专业）
工作经历：
2010.7-2012.6 北京化工大学理学院，博士后
2014.1-2015.1 Georgia Institute of Technology 化学系，访问学者
2012.7-至今 北京化工大学生命科学与技术学院，副教授
学术**：
Bioconjugate Chem., J. Med. Chem., Adv. Synth. Catal.等期刊审稿人，欧美同学会医师协会委员。
主要研究领域：
主要从事新药的设计合成，新药研发以及超分子自组装体的设计及应用等化学生物学方面的研究工作。先后主持和参与国家自然科学基金7项，博士后基金1项，科技部“十二五”医药重大专项等。近几年来，在J. Med. Chem., Chem. Euro. J., Bioconjugate Chem., Biomacromolecules,等国际知名期刊发表SCI论文30多篇，国家发明专利授权4项，日本专利PCT1项，国家科技鉴定成果1项。中国化学会会员，J. Med. Chem., Adv. Synth. Catal., Bioconjugate Chem., Bioorg. Med. Chem. Lett等期刊特约审稿人。
1. 超分子自组装体的设计及在催化、3D肿瘤细胞培养和药物载体方面的应用。
2. 智能响应型纳米药物载体的设计及在复方给药过程中的应用研究。
3. 多靶点小分子抑制剂的合成设计及体内外抗肿瘤活性评价。
获奖及荣誉：
2018年 第十五届青年优秀主讲教师，一等奖（院级），二等奖（校级）
2015年 本科招生宣传工作陕西招生组组长，二等奖（个人），三等奖（团队）
2011年 国家科技鉴定成果
2009年 杜邦奖学金
科研项目：
主持国家自然科学基金青年项目和面上项目2项，博士后基金1项，参与国家自然科学基金重点项目和面上项目5项，科技部“十二五”医药重大专项1项。与中日友好医院、北京中医院、北京大学医学部等单位开展多项合作项目。
代表性著作：
1. Mengyao Zhu, Hang Zhou, Dandan Ji, Gang Li, Fang Wang, Dingyun Song, Bo Deng, Chao Li, Renzhong Qiao. A near-infrared fluorescence probe for ultrafast and selective detection of peroxynitrite with large Stokes shift in inflamed mouse models. Dyes and Pigments, 2019, 168, 77-83. Top
2. Yilan Ju, Jintao Wu, Xi Yuan, Luqing Zhao, Ganlin Zhang, Chao Li, and Renzhong Qiao. Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4‑Anilinoquinazoline Scaffold. J. Med. Chem. 2018, 61 (24), 11372-11383. Top 封面文章
3. G. Li, D. D. Ji, S. M. Zhang, J. M. Li, C. Li*, R. Z. Qiao*. A mitochondria-targeting fluorescence turn-on probe forhypochlorite and its applications for in vivo imaging. Sens. Actuators, B. 2017, 252, 127-133. Top
4. D. D. Ji, G. Li, S. M. Zhang, M. Y. Zhu, C. Li*, R. Z. Qiao*. Mitochondria-targeted fluorescence probe for endogenoushypochlorite imaging in living cells and zebrafishs. Sens. Actuators, B. 2018, 259, 816-824. Top
5. H. Zhou, J. H. Gao, Z. H. Chen, S. Duan, C. Li*, R. Z. Qiao*. Double-strand cleavage of DNA by a polyamide-phenazine-di-N-oxide conjugate. Bioorg. Med. Chem. Lett. 2018, 28, 284-288.
6. C. Li, B. J. Cafferty, S. C. Karunakaran, G. B. Schuster, N. V. Hud. Formation of supramolecular assemblies and liquid crystals by purine nucleobases and cyanuric acid in water: implications for the possible origins of RNA. Phys. Chem. Chem. Phys., 2016, 18, 20091-20096. Top 封面文章
7. Zhang J, Zhao B, Li C, Zhu X, Qiao R*. A BODIPY-based "turn-on" fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and its application in cell imaging. Sens. Actuators, B. 2014, 196, 117-122. Top
8. H. Zhou, D. Chen, J. K. Bai, X. L. Sun, C. Li*, R. Z. Qiao*. Effect of ligand sequence-specific modification on DNA hybrid catalysis. Org. Biomol. Chem. 2017, 15, 6738-6745. 封面文章
9. J. K. Bai, H. Zhou, X. L. Sun, D. Chen, C. Li, R. Z. Qiao. Insight into Stereo-Induction by Minor Modification in the Ligand in DNA-Based Hybrid Catalysis. Catal. Lett. 2018, 148 (11), 3315-3324.
10. Z. H. CHEN, H. ZHOU, S. WANG, G. LI, J. ZHANG F. WANG, C. LI, R. Z. QIAO. An isolated method and assignment for critical impurities in semi-synthetic process of arbekacin sulfate. Pharmazie, 2019, 74, 352-356.
11. Chunying Ma, Xiao Zhang, Changguo Du, Baojing Zhao, Chunhua He, Chao Li*, and Renzhong Qiao. Water-soluble Cationic Polyphosphazenes Grafted with Cyclic Polyamine and Imidazole as An Effective Gene Delivery Vector. Bioconjugate Chem. 2016, 27, 1005-1012.
12. Ma C, Zhang J, Guo L, Du C, Song P, Zhao B, Li L, LI C*, Qiao R, Cyclen Grafted with poly[(Aspartic acid)-co-Lysine]: Preparation, Assembly with Plasmid DNA, and in Vitro Transfection Studies. Mol. Pharmaceutics 2016, 13, 47-54. Top
13. Qiao H, Ma C, Zhang X, Jing X, LI C*, Zhao Y. Insight into DNA Minor Groove Unspecific Binding of Pyrrole Polyamide. Bioconjugate Chem. 2015, 26, 2054-2061.
14. Du C, Li L, Wang H, Zhang J, Yang X, Li C*, Qiao R*, Hepatocyte targeting and sustained release activity of water-soluble anti-HBV prodrug: Lactobionic acid grafted chitosan–lamivudine conjugate. React. Funct. Polym. 2016, 98, 48-55.
15. Li L, Zhao F, Zhao B, Zhang J, Li C*, Qiao R*, Chitosan Grafted with Phosphorylcholine and Macrocyclic Polyamine as An Effective Gene Delivery Vector: Preparation, Characterization and In Vitro Transfection. Macromol. Biosci. 2015, 15, 912-916
16. Ma C, Chen H, Li C*, Zhang J, Qiao R*. IDB-containing low molecular weight short peptide as efficient DNA cleavage reagent. Org. Biomol. Chem. 2015, 13, 4524-4531.
17. Li L, Zhang J, Li C, Chen L, Qiao R*. A facile method for synthesizing water-soluble and superior sustained release anti-HIV prodrug SCs-d4T. Mater. Sci. Eng., C. 2015, 49, 84-92.
18. Zhang Y, He H, Zhang J, Liu F, Li C, Wang B, Qiao R*, HPLC-ELSD determination of kanamycin B in the presence of kanamycin A in fermentation broth. Biomed. Chromatogr. 2015, 29(3), 396-401.
19. Ma C, Li C, Luan X, Zhang J, Qiao R*, Zhao Y. Electrospray ionization mass spectrometric studies on the characteristic fragmentation of Asp/cyclen conjugates. Rapid Commun. Mass Spectrom. 2014, 28(6), 645-652.
20. Li C, Ma C, Zhang J, Qian N, Ding J, Qiao R*, Zhao Y. Design and synthesis of novel distamycin-modified nucleoside analogues as HIV-1 reverse transcriptase inhibitors. Antiviral Res. 2014, 102, 54-60.
教师寄语:
鸟随鸾凤飞腾远，人伴贤良品自高。
招生要求：
勤奋刻苦、热爱科研。不忘初心。