姓名:陈必强
职称:教授
邮箱:chenbq@mail.buct.edu.cn
工作地点:科技大厦西配楼503 |
教育背景:
2001 学士,生物化工(北京化工大学)
2003 硕士,生物化工(北京化工大学)
2008 博士,生物化工(北京化工大学)
2006/01-2006/07 赴丹麦技术大学进行博士联合培养
2008.8-2010.6 博士后(清华大学化工系)
工作经历:
2010.8-2014.12,北京化工大学生命学院,副教授,硕士生导师
2015.1-2018.1,北京化工大学生命学院,见习教授,硕士生导师
2018.1-至今,北京化工大学生命学院,教授,博士生导师
学术兼职:
lJournal of Molecular Catalysis B: Enzymatic,RSC Advance, Applied Microbiology and Biotechnology等国际期刊审稿人
主要研究领域:
长期从事生物催化剂工程的研究。作为项目负责人主持国家自然科学基金2项、国家973计划子课题2项、863计划子课题1项,企业横向课题2项。近年发表SCI论文30多篇,申请专利11项(已授权6项,包括国际专利1项)。具体研究方向:
l新酶的筛选与酶的蛋白质工程改造
l酶的固定化微环境调控
l多酶催化体系构建
l新型酶反应器设计与酶反应过程在线监测、控制与系统集成
l生物催化新产品、新工艺开发
获奖及荣誉:
2008年“以脂肪酶为催化剂的化学品绿色合成工艺”获国家技术发明奖二等奖(第二完成人)
2005年“以脂肪酶为催化剂的绿色化学合成工艺”中国石化技术发明一等奖(第三完成人)
2010年获教育部“10000个科学难题”突出贡献奖
2011获年中国微生物学会酶工程专业委员会“青年优秀论文奖”
2013年入选北京市青年英才计划
2016年入选北京市科技新星计划
代表性著作:
Selected Publications:
1)Cui C, Chen H, Chen B*, et al. Genipin Cross-Linked Glucose Oxidase and Catalase Multi-enzyme for Gluconic Acid Synthesis (2016). Applied Biochemistry and Biotechnology, 1-10.
2)Cui, C., Nan, G., Chen, X., Chen, B*., & Tan, T*. (2016). Immobilization of yarrowia lipolytica, lipase ylip 2 for the bioicatalytic synthesis of phytosterol ester in a water activity controlled reactor. Colloids & Surfaces B Biointerfaces, 146, 490-497.
3)Cui, C., Zhen, Y., Qu, J., Chen, B*., & Tan, T*. (2016). Synthesis of biosafe isosorbide dicaprylate ester plasticizer by lipase in a solvent-free system and its sub-chronic toxicity in mice. Rsc Advances, 6(15), 11959-11966.
4)Tao, Y., Dong, R., Pavlidis, I. V., Chen, B*., & Tan, T. (2015). Using imidazolium-based ionic liquids as dual solvent-catalysts for sustainable synthesis of vitamin esters: inspiration from bio- and organo-catalysis. Green Chemistry, 18(5), 1240-1248.
5)Tao, Y., Chen, G., Pavlidis, I. V., Jiang, Y., Qie, L., & Cui, C., Liu L., Chen, B*, & Tan, T.* (2015). Water-dependent kinetics guide complex lipase-mediated synthesis of biolubricants in a water activity control reactor. Catalysis Science & Technology, 5(12), 5120-5128.
6)Cui, C., Tao, Y., Ge, C., Zhen, Y., Chen, B*., & Tan, T*. (2015). Synergistic effects of amine and protein modified epoxy-support on immobilized lipase activity. Colloids & Surfaces B Biointerfaces, 133(1), 51-57.
7)Rong, X., Cui, C., Chen, B*., & Tan, T. (2015). Immobilizing yarrowia lipolytica, lipase lip2 via improvement of microspheres by gelatin modification. Applied Biochemistry & Biotechnology, 177(3), 1-9.
8)Cui, C., Xie, R., Tao, Y., Zeng, Q., Chen, B*, & Tan T*. (2015). Improving performance of yarrowia lipolytica, lipase lip2-catalyzed kinetic resolution of (R,S)-1-phenylethanol by solvent engineering. Biocatalysis & Biotransformation, 33(1), 38-43.
9)Tao, Y., Cui, C., Shen, H., Luo, L., Chen, B*., & Tan, T*. (2014). Enhancing trimethylolpropane esters synthesis through lipase immobilized on surface hydrophobic modified support and appropriate substrate feeding methods. Enzyme & Microbial Technology, 58-59(9), 60-67.
10)Chen, Biqiang,Zhang, Hong,Cheong, Ling-Zhi,Tan, Tianwei,Xu, Xuebing ,Enzymatic Production of ABA-Type Structured Lipids Containing Omega-3 and Medium-Chain Fatty Acids: Effects of Different Acyl Donors on the Acyl Migration Rate,Food and Bioprocess Technology,2012,5(2):541-547
Book Chapters:
1)Biqiang Chen, Yifeng Tao, Meng Wang, Di Cai, Tianwei Tan: Bioconversion of Biomass to Bulk Chemicals. Sustainable Production of Bulk Chemicals, 01/2016; , ISBN: 978-94-017-7473-4
2)陈必强,雷二庆、邢婉丽、刘冉、刘录祥、李奎、邱文德、李俊、刘洁,生物产业,《2017中国战略新兴产业发展报告》,中国工程科技发展战略研究院, 科学出版社, pp 124-146, 中国, 2016/11/10
教师寄语:
说真话
招生要求:
勤奋、开朗