冯嵬

教育背景：

本科（1990）、硕士（1994）、博士（1998）北京化工大学化学工程专业

工作经历：

1999年-2000年：德国柏林工业大学

2001年-2004年：荷兰代尔夫特理工大学

2005年-今：北京化工大学生命科学与技术学院

主要研究领域：

通过基因工程技术改造酶，构建酶连续催化体系；内含子介导的蛋白质剪接；手性药物中间体的酶催化合成；酶固定。

科研项目：

作为负责人承担了国家自然科学基金项目、863项目和973课题项目

代表性著作：

1. Yao Chen, Jinxin Zou, Jian Sun, Qiong Qin, Peijun Ji, Wei Feng. Immobilization using Cu(II) and Zr(IV): Persistent and highly efficient activation of galactose oxidase by in-situ generation of hydroxyl radicals in concert with in-situ generation of O2. Chemical Engineering Journal, 2022, 435, 134819.

2.     Jinxin Zou, Yao Chen, Wei Feng. Mechanism of DOPA radical generation and transfer in metal-free class Ie ribonucleotide reductase based on density functional theory. Computational and Structural Biotechnology Journal, 2022, 20, 1111–1131.

3.     Yining Han, Wenxin Qu, Wei Feng. Coupling a recombinant oxidase to catalase through specific noncovalent interaction to improve the oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid.Enzyme and Microbial Technology, 2021, 150, 109895.

4.   Rong Li, Yao Chen, Kun Du, Wei Feng. Peptide Bond Formation Between the Hetrosubunits of ω-Transaminase, Alanine Dehydrogenase, and FormateDehydrogenase Through Subunit Splicing Promoted by Heterodimerization of Leucine Zipper Motifs. Frontiers in Bioengineering and Biotechnology. 2020, 8, 686,1-13.

5.     Yao Chen, Hao Chu, Wei Liu, Wei Feng. Simultaneous synthesis of L-DOPA and oxidation of D-amino acid by specific coupling of a peroxidase to D-amino acid oxidase. Enzyme and Microbial Technology,2019,121, 8–16.

6.     Jian Sun, Yaqi Fu, Rong Li, Wei Feng. Multifunctional Hollow−Shell Microspheres Derived from Cross-Linking of MnO2 Nanoneedles by Zirconium-Based Coordination Polyme: Enzyme Mimicking, Micromotors, and Protein Immobilization. Chemistry of Materials. 2018, 30, 1625−1634.

7.     Rong Li, Xiaoqi Zhou, Dan Liu, Wei Feng. Enhancing the activity and stability of Mn-superoxide dismutase by one-by-one ligation to catalase.Free Radical Biology and Medicine, 2018, 129, 138-145.

8.     Kun Du,Jinjin Zhao,Jian Sun, and Wei Feng. Specific Ligation of Two Multimeric Enzymes with Native Peptides and Immobilization with Controlled Molar Ratio. Bioconjugate Chemistry. 2017, 28, 1166−1175..

9.     Jian Sun, Kun Du, Xiaoqiang Song, Qian Gao, Jingjing Ma, Wei Feng. Specific Immobilization of D-amino Acid Oxidase Mimicking Multi-enzyme Catalysis. Green Chemistry. 2015, 17, 4465–4472.

10.  Jian Sun, Kun Du, Li Fu,Jiang Gao,Haiyang Zhang,Wei Feng. Sodium Hexadecyl Sulfate as an Interfacial Substance Adjusting the Adsorption of a Protein on Carbon Nanotubes. ACS Appl. Mater. Interfaces. 2014, 6, 15132− 15139.

11.  Kun Du, Jian Sun,Xiaoqiang Song,Huaming Chen,Wei Feng, Peijun Ji. Interaction of Ionic Liquid [bmin][CF3SO3] with Lysozyme Investigated by Two-Dimensional Fourier Transform Infrared Spectroscopy. ACS Sustainable Chemistry & Engineering. 2014, 2, 1420−1428.

12.   Wei Feng, Peijun Ji. Enzymes immobilized on carbon nanotubes. Biotechnology Advances. 2011, 29, 889-895. 

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