王艳东

发布时间:2019-10-31

姓名:王艳东 

 

职称:教授

 

邮箱:ydwang@mail.buct.edu.cn   


基本信息:

王艳东,女,教授,博士生导师。近年在受体信号通路和新药靶向鉴定方面开展了具有国际影响的前沿研究,取得重要成果。鉴定出新的炎症和肝癌负调节子并发现其分子机制。研究成果多次被国际上有影响的期刊和杂志专题报道。目前,开展的研究工作主要针对两个方面:一是核受体和膜受体在肝脏的损伤和再生,炎症和癌症发病的分子机制方面的研究;另一个是植物细胞培养提取药用成分以及蛋白质和天然产物药物的纯化和制备。相关的研究工作涉及上游分子机制和信号通路的确定及相关药物靶向的鉴定,以及下游的药物筛选、纯化和制备。欢迎有志于在生物医学领域做出成绩的研究生报考。         


教育背景:

博士阶段 (2000年3月-2003年3月)    天津大学化工学院

硕士阶段 (1998年9月-2000年1月)    天津大学化工学院

本科阶段 (1993年9月-1997年6月)    天津大学化工学院


工作经历:

2013年5月-现在  北京化工大学生命科学与技术学院,教授,博士生导师

2011年7月-2013年2月 研究助理教授(Research Assistant Professor)美国东北俄亥俄医科大学

2010年10月-2011年6月 Staff Scientist研究员(Staff Scientist)美国国家医学中心贝克曼研究所

2006年3月-2010年9月 博士后(Postdoctoral Research Fellow)美国国家医学中心贝克曼研究所

2004年4月-2005年10月 博士后(Postdoctoral Research Fellow)德国国家环境与健康研究中心


学术**:

American Gastroenterological Association, 会员

Frontiers in Pharmacology, reviewer editor,2017-

北京化工大学学报,编委 2016-

Journal of Gastroenternology and Hepatology 编委,审稿人

Plos One, Oncotarget, Cancer Letters 审稿人

北京化工大学学报,编委,2016-

Biomed Research International 期刊特邀专题编辑,2015-

国家留学基金委国家公派研究生项目评委, 2014-

国家留学基金委国家公派高级访问学者项目评委,2015-


主要研究领域:

1.核受体和膜受体在炎症和癌症中的作用机理研究;

2.受体在肝再生过程中的分子机制研究;

3.受体在代谢病中的作用研究;

4.小RNA(miRNA)在炎症、癌症和代谢病中的分子机制研究

5.植物细胞培养提取药用成分暨基于受体在炎症和癌症中作用的相关药物开发


获奖及荣誉:

1. Poster of Distinction Award, Digestive Disease Week, San Diego, USA, May 2012

2. City of Hope GI Cancer Program GI Cancer Research Pilot Project Award, City of Hope National Cancer Center, California, USA, October 2010

3. 2016年度北京化工大学三八红旗手


代表性著作:

发表在国际SCI源期刊的学术论文(英文期刊)

1 Lv, X, Kong, J, Chen, W.-D., Wang, Y.-D.. The Role of the Apelin/APJ System in the Regulation of Liver Disease. Front Pharmacol. 2017, In press.

2 Su, J., Zhang, Q., Qi, H., Wu, L., Li, Y., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D.. The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling

pathways. Oncotarget, 2017, in press.

3 Xue, F., Nie, X., Shi, J., Liu, Q., Wang, Z., Li, X., Zhou, J., Su, J., Xue, M., Chen, W.-D., Wang, Y.-D. Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition. Front Pharmacol. 2017 Feb 3;8:40. doi: 10.3389/fphar.2017.00040.

4 Guo, C., Chen, W.-D., Wang, Y.-D. TGR5, Not Only a Metabolic Regulator. Front Physiol. 2016 Dec 26;7:646. doi: 10.3389/fphys.2016.00646.

5 Wang, H., Nie, X., Wu, R., Yuan, H., Ma, Y., Liu, X., Zhang, J., Deng, X., Na, Q., Jin, H., Bian, Y., Gao, Y., Wang, Y.-D., * Chen, W.-D.. * Down-regulation of human Wnt3 in gastric cancer suppresses cell proliferation and induces apoptosis, OncoTargets and Therapy. 2016 Jun 27;9:3849-60. doi: 10.2147/OTT.S101782.

6 Guo, C., Su, J., Li, Z., Xiao, R., Wen, J., Li, Y., Zhang, M., Zhang, X., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D..* The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway. Oncotarget. 2015,27; 6(33):34402-34413. (Top, SCI一区,影响因子5.0)

7 Guo, C., Qi, H., Yu, Y., Zhang, Q., Su, J., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D..* The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-kB signaling pathway. Front. Pharmacol. 2015,6:287., doi: 10.3389/fphar.2015.00287(SCI二区,影响因子4.4)

8 Sun, X., Chen, W.-D., Wang, Y.-D..* β-Amyloid:the key peptide in the pathogenesis of Alzheimer’sdisease. Front. Pharmacol. 2015,6:221., doi:10.3389/fphar.2015.00221 (SCI二区,影响因子4.4)

9 Wang, Y.-D,* W.-D. Chen, C. Li, , C. Guo, , Y. Li, , H. Qi,, H. Shen, J. Kong, , X. Long, , F.  Yuan, , X. Wang, , W. Huang. Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by Activating SOD3. Mol Endocrinol. 2015,29(2):322-331.(SC二区,影响因子为4.54)

10 Lou, G., Ma, X., Fu, X., Meng, Z., Zhang, W., Wang, Y.-D., Van, Ness C., Yu, D., Xu, R., Huang, W. Gpbar1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells. PloS One. 2014, 9(4):e93567. (SCI, 影响因子3.2, SCI被引4次)

11 Wang, Y.-D.*, Chen, W.-D., Yu, D., Forman, B.M and Huang, W. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology. 2011, 54(4), 1421-1432. (国际肝病学排名第一的学术期刊,SCI一区,影响因子为12.003)

•Faculty of 1000 Biology推荐必读论文

12 Chen, W.-D.*, Wang, Y.-D.*, Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B.M and Huang, W. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology. 2010, 51(3), 953-962.(国际肝病学排名第一的学术期刊,SCI一区,影响因子为12.003)

*同等贡献第一作者

13 Chen, W.-D.*, Wang, Y.-D.*, Meng, Z., Zhang, L. and Huang, W. Nuclear bile acid receptor FXR in the hepatic regeneration. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2011, 1812(8), 888-892. (SCI二区,影响因子为5.387)

*同等贡献第一作者

14 Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B.M. and Huang, W.  Farnesoid X receptor antagonizes NF-κB in hepatic inflammatory response. Hepatology. 2008, 48(5), 1632-1643.(国际肝病学排名第一的学术期刊,SCI一区,影响因子为12.003)

•该研究工作的重要意义被影响因子分别为11.68和11.67的国际学术期刊Gastroenterology(2009, 137(2), 734-735)和Hepatology(2008, 48(5), 1383-1386)专题评价

•Faculty of 1000 Biology推荐必读论文

•基于该发现,目前国际上已经开发出FXR的特异性抑制剂用于临床治疗。

15 Wang, Y.-D., Chen, W.-D. and Huang, W. FXR: a metabolic regulator and a cell protector. Cell Research. 2008, 18(11), 1087-1095.(SCI一区,影响因子为8.19)

•Faculty of 1000 Medicine推荐必读论文

16 Wang, Y.-D., Yang, F., Chen, W.-D., Huang, X., Lai, L., Forman, B.M. and Huang, W. Farnesoid x receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Molecular Endocrinology. 2008, 22(7), 1622-1632.(SCI二区,影响因子为4.54)

•该研究工作被Endocrine News(2008, July, 13)专题报道

17 Wang, Y.-D., Chen, W.-D. and Huang, W. FXR, a target for different diseases. Histology and Histopathology. 2008, 23(5), 621-627.(SCI三区,影响因子为2.48)

18 Wang, Y.-D., Wu, J. and Yuan, Y.-J. Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. Cell Biology International. 2007, 31(10), 1179-1183.(SCI四区,影响因子为1.48)

19 Wang, Y.-D., Yan, Y.-J. and Wu, J. Induction studies of methyl ja**onate and salicylic acid on taxane production in suspension cultures of Taxus chinensis var. mairei. Biochemical Engineering Journal. 2004, 19 (3), 259-265.

20 Wang, Y.-D., Yan, Y.-J. and Wu, J. Translocation of isopentenyl pyrophosphate for Taxol biosynthesis in suspension cultures of Taxus chinensis var. mairei. Plant Cell, Tissue and Organ Culture. 2003, 74, 283-288.

21 Wang, Y.-D., Yan, Y.-J., Lu, M, Wu, J. and Jiang, J.-L. Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei. Biotechnology and Applied Biochemistry. 2003, 37 (1), 39-43.

22 Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B.M. and Huang, W. Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine. Hepatology. 2012,56(6),2336-2343 (国际肝病学排名第一的学术期刊,SCI一区,影响因子为12.003)

23 Meng, Z., Wang, Y.-D., Wang, L., Jin, W., Liu, N., Pan, H., Liu, L., Wagman, L., Forman, B.M and Huang, W. FXR regulates liver repair after CCl4-induced toxic injury. Molecular Endocrinology. 2010, 24(5), 886-897.

24 Chen, W.-D., Wang, Y.-D., Hu, H.-H. and Su, Z.-G. Hydrodynamics in an expanded bed of large size ion-exchange resin, and natural product adsorption. Journal of Chemical Technology and Biotechnology. 2007, 82, 135–142.

25 Chen, W.-D., Wang, Y.-D. and Su, Z.-G. Suitability of steric mass-action model for ion-exchange equilibrium of micromolecule. Chinese Journal of Chemical Engineering. 2005, 13 (1), 17-22.

26 Chen, W.-D., Wang, Y.-D., Zha L.-H., Ma, G.-H. and Su, Z.-G. Single-step recovery of ephedrine hydrochloride from raw materials using expanded bed adsorption. Biotechnology Letters. 2004, 26,1233-1236.

27 Schoetz, U., Cervelli, M., Wang, Y.-D., Fiedler, P. and Buerstedde, J.-M. E2A expression stimulates Ig hypermutation. Journal of Immunology. 2006, 177(1), 395-400.

28 Chen, W.-D., Hu, H.-H. and Wang, Y.-D. Analysis of steric mass-action model for protein adsorption equilibrium onto porous anion-exchange adsorbent. Chemical Engineering Science. 2006, 61, 7068-7076.

29 Ge, Z., Yuan, Y.-J., Wang, Y.-D., Ma, Z. and Hu. Z. Ce4+-induced apoptosis of Taxus cuspidata cells in suspension cultures. Journal of Rare Earths. 2002, 20,139-144.

30 Chen, W.-D., Fu, X., Dong, B., Wang, Y.-D., Shiah, S., Moore, D.D and Huang, W. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metaboli** in mouse liver. Hepatology. 2012,56(4),1499-1509.(国际肝病学排名第一的学术期刊,SCI一区,影响因子为12.003)

31 Meng, Z., Liu, N., Fu, X., Wang, X., Wang, Y.-D., Chen, W.-D., Zhang, L., Forman, B.M and Huang, W. Insufficient bile acid signaling impairs liver repair in CYP27-/- mice. Journal of Hepatology. 2011, 55(4), 885-895. (SCI一区,影响因子为12.003)

32 Wahl, M.B., Caldwell, R.B., Kierzek, A.M., Arakawa1, H., Eyras, E., Hubner, N., Jung, C., Soeldenwagner, M., Cervelli1, M., Wang, Y.-D., Liebscher, V. and Buerstedde. J.-M. Evaluation of the chicken transcriptome by SAGE of B cells and the DT40 cell line. BMC Genomics. 2004, 5:98 (http://www. Biomedcentral.com/1471-2164/5/98)


教师寄语:

我们的研究团队是一个大家庭,希望加入大家庭的每位同学都能得到科研技能、人生智慧和生活态度的提升。


招生要求:

真诚、踏实、学习和工作效率高、有较好的英语基础