田平芳

发布时间:2019-10-31

 

姓名:田平芳

 

职称:教授


tianpf@mail.buct.edu.cn

 

办公地址:科301


教育背景:

2003年浙江大学博士学位,美国加州大学圣地亚哥分校(University of California, San Diego)访问学者,美国佐治亚大学(University of Georgia)高级研究学者。


工作经历:

2000年以前在河北省农林科学院等单位工作;200310月到北京化工大学工作至今,担任教授和博士生导师,已培养博士及硕士研究生62人。


学术兼职:

Appl Envir Microbiol, Metab Eng,Biotechnol Adv,Biotechnol Bioeng,ACS Synth Biol,Appl Microb Biotechnol,Biotechnol Biofuels,Scientific Reports, Microbial Cell Factories,Bioresour Technol,Process Biochem, Mol Genetics Genomics30多个SCI期刊审稿人,塔里木大学兼职教授,国家留学基金评审专家,国家及多个省市自然科学基金函评专家。


主要研究领域:

1.微生物代谢工程:用基因工程法生产大宗或高值化学品,包括3-羟基丙酸、1,3-丙二醇、工业用酶、新材料聚3-羟基丙酸、新型维生素吡咯喹啉醌、抗癌药阿霉素、阿克拉霉素等。

2.合成生物学:以提高发酵产量为目标的关键基因筛选、基因组编辑、目标代谢途径耦合强化、全局代谢调控、细胞逻辑预设、鲁棒性改良、正交表达系统构建乃至中心法则重构等。

3.应用微生物选育及发酵:包括工业发酵和环境修复微生物的选育,发酵条件优化和智能自动控制。

4.分离工程:微生物发酵代谢物及天然产物的高效分离技术。

5.生物农药:天然抗菌活性成分的筛选、剂型制备及应用推广。

 

围绕上述研究方向,主持国家自然科学基金(NSFC)、863重点课题、国家重点研发计划课题、省市及企业委托项目20多项。本实验室基础和应用研究并重,发表SCI和核心期刊文章130多篇,授权专利25项;若干化学品发酵产量居世界领先水平;研发的多种剂型天然生物农药已在全国多省份推广,产生了良好经济和生态效益。


代表性著作:

1)       Charting the landscape of RNA polymerases to unleash their potential in strain improvement. Biotechnology Advances, 2021, 107792. doi: 10.1016/j.biotechadv.2021.107792. (一区Top, IF=14.227,通讯作者)

2)       Switching metabolic flux by engineering tryptophan operon-assisted CRISPR interference system in Klebsiella pneumoniae. Metabolic Engineering, 2021, 65, 30-41(一区Top, IF=9.783, 通讯作者)

3)       Biosynthesis pathways and strategies for improving 3-hydroxypropionic acid production in bacteria. World J Microbiol Biotechnol, 2021, 37(7): 117 (通讯作者)

4)       A rapid liquid chromatography-electrospray ionization-ion mobility spectrometry method for monitoring nine representative metabolites in the seedlings of cucumber and wheat. Journal of Separation Science, 2021, 44(3): 709-716 (通讯作者)

5)       Intensifying niacin-based biosynthesis of NAD+ to enhance 3-hydroxypropionic acid production in Klebsiella pneumoniae. Biotechnol Lett, 2021, 43(1): 223-234  (通讯作者)

6)       Development of T7 expression system in Klebsiella pneumoniae. Biotechnology and Bioengineering, 2020, 117, 2446-2459 (Top杂志, 通讯作者)

7)       Engineering CRISPR interference system to repress Class 1 integron in E. coli. Antimicrob Agents Chemother, 2020, 64(3): e01789-19 (Top杂志, 通讯作者)

8)       CRISPR interference-guided modulation of glucose pathways to boost aconitic acid production in Escherichia coli. Microbial Cell Factory, 2020, 19(1):174. doi: 10.1186/s12934-020-01435-9 (通讯作者)

9)       Engineering CRISPR interference system to enhance the production of pyrroloquinoline quinone in Klebsiella pneumoniae. Lett Appl Microbiol, 2020, 71(3): 242-250 (通讯作者)

10)    Improved production of pyrroloquinoline quinone by simultaneous augmentation of its synthesis gene expression and glucose metabolism in Klebsiella pneumoniae. Curr Microbiol, 2020, 77(7): 1174-1183 (通讯作者)

11)    Overview of Alternaria alternata membrance proteins. Indian J Microbiol, 2020, 60(3): 269-282 (通讯作者)

12)    Exploiting tandem repetitive promoters for high-level production of 3-hydroxypropionic acid. Appl Microbiol Biotechnol, 2019, 103(10): 4017-4031 (Top杂志, 通讯作者)

13)    Physiological investigations of the influences of byproduct pathways on 3-hydroxypropionic acid production in Klebsiella pneumoniae. J Basic Microbiol, 2019, 59(12):1195-1207 (通讯作者)

14)    Two-dimensional analysis of phenolic acids in seedling roots by high performance liquid chromatography-electrospray ionization-ion mobility spectrometry. Analytical Methods, 2019, 11, 610-617(通讯作者)

15)    Multipath effects of berberine on peach brown rot fungus Monilinia fructicola. Crop Protection, 2019, 116, 92-100(通讯作者)

16)    Development of cyclic AMP receptor protein-based artificial transcription factor for intensifying gene expression. Appl Microbiol Biotechnol, 2018, 102(4): 1673-1685 (Top杂志, 通讯作者)

17)    Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis. Microbial Cell Factories, 2018, 17(1): 56-67 (通讯作者)

18)    Fundamental CRISPR-Cas9 tools and current applications in microbial systems. Systems and Synthetic Biology, 2017, 2(3): 219-225 (一作)

19)    Evaluation of Berberine as a natural compound to inhibit peach brown rot pathogen Monilinia fructicola. Crop Protection, 2017, 91, 20-26 (通讯作者)

20)    High production of 3-hydroxypropionic acid in Klebsiella pneumoniae by systematic optimization of glycerol metabolism. Scientific Reports, 2016, 6, 26932  (通讯作者)

21)    Enhanced Promoter Activity by Replenishment of Sigma Factor RpoE in Klebsiella pneumoniae. Indian J Microbiol, 2016, 56(2): 190-197 (通讯作者)

22)    Development of Red recombinase system and antisense RNA technology in Klebsiella pneumoniae for production of chemicals. RSC Advances, 2016, 6, 79920-79927  (通讯作者)

23)    3-Hydroxypropionaldehyde-specific aldehyde dehydrogenase from Bacillus subtilis catalyzes 3-hydroxypropionic acid production in Klebsiella pneumoniaeBiotechnol Lett, 2015, 37(3): 717-724, 2015  (通讯作者)

24)    NAD+-independent aldehyde oxidase catalyzes cofactor balanced 3-hydroxypropionic acid production in Klebsiella pneumoniaeBiotechnol Lett, 2014, 36(11): 2215-2221  (通讯作者)

25)    Distinct promoters affect pyrroloquinoline quinone production in recombinant Escherichia coli and Klebsiella pneumoniaeCurr Microbiol, 2014, 69(4): 451-456  (通讯作者)

26)    Enhanced aldehyde dehydrogenase activity by regenerating NAD+ in Klebsiella pneumoniae and implications for the glycerol dissimilation pathways. Biotechnol Lett, 2013, 35(10): 1609-1615 (通讯作者)

27)    Engineered constitutive pathway in Klebsiella pneumoniae for 3-hydroxypropionic acid production and implications for decoupling glycerol dissimilation pathways. Curr Microbiol, 2013, 66(3): 293-299 (通讯作者)

28)    Disease control during peach preservation with a berberine-chitosan composite membrane. Fruits, 2012, 67(4): 277-284 (通讯作者)

29)     Classifying the DNA assembly protocols for devising cellar architectures. Biotechnology Advances, 2011, 29(1): 156-163 (一区Top, 通讯作者)

30)    Berberine as a natural compound inhibits the development of brown rot fungus Monilinia fructicolaCrop Protection, 2010, 29, 979-984 (通讯作者)


中文文章:

1)       生物合成薯蓣皂素的途径设计及关键酶分析. 生物工程学报, 2021, 37(4): 1178-1188(通讯作者)

2)       半导体合成生物学的研究进展. 化工学报, 2021, 72(5): 2426-2435 (通讯作者)

3)       重组肺炎克雷伯氏菌转化甘油为聚3-羟基丙酸. 中国生物工程杂志, 2017, 37(6): 86-92(通讯作者)

4)       肺炎克雷伯氏菌毒力因子的研究进展. 微生物学报, 2015, 55(10): 1245-1252 (通讯作者)

5)       羧酶体结构及其CO2浓缩机制研究进展.生物工程学报, 2014, 30(8): 1164-1171 (通讯作者)

6)       小檗碱壳聚糖微球制备及其抗病原真菌活性测定. 过程工程学报, 2008, 8(5): 962-966(通讯作者)

7)       链球菌生物合成透明质酸的分子机理与基因工程菌构建进展. 中国生物工程杂志,2008, 28 (4): 98-102(通讯作者)

8)       淡豆豉、黄大豆及黑大豆体内外抗蛋白非酶糖化作用研究. 食品科学, 2008, 29(10): 557-559 (通讯作者)

9)       遗传改造Klebsiella pneumoniae提高1,3-丙二醇产量的研究进展. 化工进展, 2008, 27(3): 322-325 (一作)

10)    甘油歧化为1,3-丙二醇的代谢及关键酶研究进展,生物工程学报, 2007, 23(2): 201-205(一作)

 

此外,发表其他SCI和中文文章90多篇(略),授权专利25件(略)。


教师寄语:

宁静致远,天道酬勤


招生要求:

热爱科研,踏实认真