乔仁忠

发布时间:2019-10-31

姓名:乔仁忠

 

职称:教授

 

邮箱:qiaorz@mail.buct.edu.cn

 

办公地址:科技大厦西配楼416


 

 


教育背景:

1999.9-2002.6  兰州大学     化学化工学院,     博士   研究方向:杂环与杂原子化学

1989.9-1992.6  河南师范大学 化学与环境工程学院,硕士   研究方向:有机合成


工作经历:

2002.9-2004.9  清华大学化学系,博士后,研究方向:有机合成及化学生物学

2004.9-至今    北京化工大学生命科学与技术学院,教授,博士生导师


学术**:

    科技部、国家自然科学基金委、教育部及多省市各种相关领域项目评审专家,国内外重要学术期刊特约审稿人。


主要研究领域:

   致力于药物化学和化学生物学方向的研究工作。利用化学的理论、方法、手段和策略,发现和构建新颖的生物活性分子,探索其与生物体靶分子间的相互作用、分子识别和信息传递, 阐明各种生理和病理过程的分子机制,旨在解决重要的生命及生物医学问题。同时也为制药企业提供合成理论技术支持与生产工艺优化。

 1. 多靶点小分子抑制剂的合成设计及体内外抗肿瘤活性评价。

 2. 新药研发及工艺路线的优化。

 3. 智能响应型纳米药物载体的设计及性能研究。

 4. 超分子自组装体的设计及在催化、3D肿瘤细胞培养和药物载体方面的应用。


获奖及荣誉:

授权专利12, 省部级二等、三等奖各1项,科学技术鉴定成果3项。


科研项目:

    主要从事新药的设计合成,仿制药工艺设计优化及化学生物学等领域的研究工作。先后主持国家自然科学基金面上项目6项,合作主持国家自然科学基金重点项目2项,联合主持科技部十二五医药重大专项1项,与多家制药企业集团进行产学研合作研究。


代表性著作(通讯作者)

1. Mengyao Zhu, Hang Zhou, Dandan Ji, Gang Li, Fang Wang, Dingyun Song, Bo Deng, Chao Li, Renzhong Qiao. A near-infrared fluorescence probe for ultrafast and selective detection of peroxynitrite with large Stokes shift in inflamed mouse models. Dyes and Pigments, 2019, 168, 77-83. Top

2. Yilan Ju, Jintao Wu, Xi Yuan, Luqing Zhao, Ganlin Zhang, Chao Li, and Renzhong Qiao. Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4Anilinoquinazoline Scaffold. J. Med. Chem. 2018, 61 (24), 11372-11383. Top 封面文章

3. G. Li, D. D. Ji, S. M. Zhang, J. M. Li, C. Li*, R. Z. Qiao*. A mitochondria-targeting fluorescence turn-on probe forhypochlorite and its applications for in vivo imaging. Sens. Actuators, B. 2017, 252, 127-133. Top

4. D. D. Ji, G. Li, S. M. Zhang, M. Y. Zhu, C. Li*, R. Z. Qiao*. Mitochondria-targeted fluorescence probe for endogenoushypochlorite imaging in living cells and zebrafishs. Sens. Actuators, B. 2018, 259, 816-824. Top

5. H. Zhou, J. H. Gao, Z. H. Chen, S. Duan, C. Li*, R. Z. Qiao*. Double-strand cleavage of DNA by a polyamide-phenazine-di-N-oxide conjugate. Bioorg. Med. Chem. Lett. 2018, 28, 284-288.

6. Zhang J, Zhao B, Li C, Zhu X, Qiao R*. A BODIPY-based "turn-on" fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and its application in cell imaging. Sens. Actuators, B. 2014, 196, 117-122. Top

7. H. Zhou, D. Chen, J. K. Bai, X. L. Sun, C. Li*, R. Z. Qiao*. Effect of ligand sequence-specific modification on DNA hybrid catalysis. Org. Biomol. Chem. 2017, 15, 6738-6745. 封面文章

8. J. K. Bai, H. Zhou, X. L. Sun, D. Chen, C. Li, R. Z. Qiao. Insight into Stereo-Induction by Minor Modification in the Ligand in DNA-Based Hybrid Catalysis. Catal. Lett. 2018, 148 (11), 3315-3324.

9. Z. H. CHEN, H. ZHOU, S. WANG, G. LI, J. ZHANG F. WANG, C. LI, R. Z. QIAO. An isolated method and assignment for critical impurities in semi-synthetic process of arbekacin sulfate. Pharmazie, 2019, 74, 352-356.

10. Chunying Ma, Xiao Zhang, Changguo Du, Baojing Zhao, Chunhua He, Chao Li*, and Renzhong Qiao. Water-soluble Cationic Polyphosphazenes Grafted with Cyclic Polyamine and Imidazole as An Effective Gene Delivery Vector. Bioconjugate Chem. 2016, 27, 1005-1012.

11. Ma C, Zhang J, Guo L, Du C, Song P, Zhao B, Li L, LI C*, Qiao R, Cyclen Grafted with poly[(Aspartic acid)-co-Lysine]: Preparation, Assembly with Pla**id DNA, and in Vitro Transfection Studies. Mol. Pharmaceutics 2016, 13, 47-54. Top

12.  Du C, Li L, Wang H, Zhang J, Yang X, Li C*, Qiao R*, Hepatocyte targeting and sustained release activity of water-soluble anti-HBV prodrug: Lactobionic acid grafted chitosan–lamivudine conjugate. React. Funct. Polym. 2016, 98, 48-55.

13. Li L, Zhao F, Zhao B, Zhang J, Li C*, Qiao R*, Chitosan Grafted with Phosphorylcholine and Macrocyclic Polyamine as An Effective Gene Delivery Vector: Preparation, Characterization and In Vitro Transfection. Macromol. Biosci. 2015, 15, 912-916

14. Ma C, Chen H, Li C*, Zhang J, Qiao R*. IDB-containing low molecular weight short peptide as efficient DNA cleavage reagent. Org. Biomol. Chem. 2015, 13, 4524-4531.

15.  Li L, Zhang J, Li C, Chen L, Qiao R*. A facile method for synthesizing water-soluble and superior sustained release anti-HIV prodrug SCs-d4T. Mater. Sci. Eng., C. 2015, 49, 84-92.

16. Zhang Y, He H, Zhang J, Liu F, Li C, Wang B, Qiao R*, HPLC-ELSD determination of kanamycin B in the presence of kanamycin A in fermentation broth. Biomed. Chromatogr. 2015, 29(3), 396-401.

17. Ma C, Li C, Luan X, Zhang J, Qiao R*, Zhao Y. Electrospray ionization mass spectrometric studies on the characteristic fragmentation of Asp/cyclen conjugates. Rapid Commun. Mass Spectrom. 2014, 28(6), 645-652.

18.  Li C, Ma C, Zhang J, Qian N, Ding J, Qiao R*, Zhao Y. Design and synthesis of novel distamycin-modified nucleoside ****ogues as HIV-1 reverse transcriptase inhibitors. Antiviral Res. 2014, 102, 54-60. 


导师寄语:

天道酬勤


招生要求:

热爱科研、努力勤奋,英语水平优秀。