姓名：朱玉山 职称：教授，博士生导师 邮箱：zhuys@mail.buct.edu.cn 办公地址： 东校区计算机西楼408-410 生命科学与技术学院 北京化工大学 北京市朝阳区北三环东路15号 |
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教育背景：
1993，天津大学， 化学工程，学士
1996，天津大学， 化学工程，硕士
1999，中国科学院，化学工程，博士
工作经历：
2021-至今，北京化工大学生命学院，教授
2004-2020，清华大学化工系，副教授
2001-2003，日本筑波大学，JSPS博士后
主要研究领域：
主要从事计算酶设计、酶催化、生物化工及合成生物学的研究。独立开发了计算酶设计的平台PRODA，结合蛋白质结构预测、量化计算、分子动力学模拟、机器学习及低通量实验，可以实现针对非天然底物及非天然反应设计新酶分子，助力化工、能源、材料、环保、医药、食品等多个行业实现绿色生物制造。
代表性著作：
[10] P Wang, S Zhang, J Zhang, Y Zhu*. Computational design of penicillin acylase variants with improved kinetic selectivity for the enzyme synthesis of cefazolin. Biochemical Engineering Journal. 2021, 175: 108149.
[9] J Xue, P Wang, J Kuang, Y Zhu*. Computational design of new enzymes for hydrolysis and synthesis of third-generation cephalosporin antibiotics. Enzyme and Microbial Technology. 2020, 140: 109649.
[8] S Zhang, J Zhang, Y Zhu*. ProdaMatch: A fast and accurate active site matching algorithm for de novo enzyme design. Computers and Chemical Engineering. 2020, 140: 106921.
[7] M Lin, F Wang, Y Zhu*. Modeled structure-based computational redesign of a glycosyltransferase for the synthesis of rebaudioside D from rebaudioside A. Biochemical Engineering Journal. 2020, 159: 107626.
[6] J He, X Huang, J Xue, Y Zhu*. Computational redesign of penicillin acylase for cephradine synthesis with high kinetic selectivity. Green Chemistry. 2018, 20: 5484.
[5] Z Xu, Y Tian, Y Zhu*. Computational design of thermostable mutants for cephalosporin C acylase from Pseudomonas strain SE83. Computers and Chemical Engineering. 2018, 116: 112.
[4] X Huang, J Xue, M Lin, Y Zhu*. Computational design of cephradine synthase in a new scaffold identified from structural databases. Chemical Communications. 2017, 53: 7604.
[3] Y Tian, X Huang, Q Li, Y Zhu*. Computational design of variants of cephalosporin C acylase from Pseudomonas strain N176 with improved stability and activity. Applied Microbiology and Biotechnology. 2017, 101: 621.
[2] X Huang, K Han, Y Zhu*. Systematic optimization model and algorithm for binding sequence selection in computational enzyme design. Protein Science. 2013, 22: 929.
[1] Y Lei, W Luo, Y Zhu*. A matching algorithm for catalytic residue site selection in computational enzyme design. Protein Science. 2011, 20：1566.
教师寄语：
持之以恒、坚持不懈
招生要求：
欢迎生物、化学、工程及计算机科学等背景（不限）的学生加入实验室，以科研助理、博士后、博士生、硕士生或本科生等进行科研工作。招生咨询请发送邮件到：zhuys@mail.buct.edu.cn。