张桂敏

发布时间:2019-10-31


姓名:张桂敏

 

职称:教授

 

邮箱:zhangguimin@mail.buct.edu.cn



办公地址:东校区计算机西楼302

 


  

教育背景:

1993.09-1997.06,华中农业大学生科院,微生物学学士学位

1997.09-2000.06,华中农业大学生科院,生物化学与分子生物学硕士学位

2003.09-2006.06,华中农业大学生科院,微生物学博士学位


工作经历:  

2007.11-2011.09,中国科学院微生物研究所,博士后

2011.10-2012.10,美国佛罗里达大学,访问学者

2015.07-2015.08,德国汉堡工业大学,访问学者

2000.07-2021.07,湖北大学生命科学学院教师

2021.08-         北京化工大学生命科学与技术学院教授


学术兼职:

科技部工业酶产业技术创新战略联盟专家委员会成员、副秘书长;

中国生物发酵产业协会第三届理事会理事

湖北省暨武汉微生物学会酶工程专业委员会主任委员

湖北省暨武汉微生物学会真菌专业委员会副主任委员

湖北省暨武汉微生物学会常务理事


获奖及荣誉:

     2020年,湖北省中青年突出贡献专家

2020年,湖北省博士后卓越人才跟踪培养计划资助人选(全省10名)

2019年,指导本科生HUBU-WUHAN团队获iGEM2019银奖

2019年,指导2017级本科生作品低聚半乳糖醛酸的功能性产品应用获第四届全国大学生生命科学创新创业大赛创业类一等奖

2019年,指导2017级本科生获湖北省品酒大赛一等奖

2019年,湖北大学优秀共产党员

2018年,湖北省新世纪高层次人才工程

2018年,三效复合饲用抗生素替代技术获中国科技产业化促进会科技创新一等奖(第二署名)

2018年,废弃物发酵制备饲用微生态制剂关键技术及产业化获湖北省科技进步三等奖(第一署名)

2018年,湖北省杰出青年基金

2017年,湖北大学首届五四青年奖章

2017年,武汉市黄鹤英才

2016年,三效复合饲用抗生素替代技术获湖北高校十大科技成果转化项目;

2016年,-寡糖-菌三效复合饲用抗生素替代技术获湖北省科技进步二等奖(第二署名);

2016年,兼性嗜碱菌Bacillus pseudofirmus新亚家族碱性淀粉酶的研究荣获“2016年中国微生物学会学术年会优秀学术论文奖

2015年,耐热壳聚糖酶高产菌株的构建及酶法制备壳寡糖获湖北省科技进步三等奖(第二署名);

2015年,获武汉新华扬奖教金;

2014,湖北省暨武汉市微生物学会授予真菌学青年优秀人才奖

2013年,湖北省高端人才培养计划第二层次人选;

2012年,霍英东青年教师奖三等奖(全国两年仅有100人获霍英东青年教师奖);

2013年、2012年,2011年,2010年,2009年连续五年指导本科生获湖北省优秀本科毕业论文;


主要研究方向: 

主要从事微生物酶制剂及相关产品的研发工作,擅长酶的分子改造和高效表达技术。先后主持国家自然科学基金5项、国家重点研发计划课题和子课题各1项,国家“863”计划子课题2项,湖北省、武汉市科技计划和各类横向课题20余项。近 5 年授权发明专利13项,实现成果转让6项。具体研究方向包括:

1. 酶的蛋白质工程改造与高效表达

2. 真菌毒素降解

3.食品、环境中有毒污染物的生物传感


代表性著作: 

1. Congna Li#(2021届硕士生), Shun Jiang#(2019届硕士生), Chao Du, Zhenghui Lu, Nisha He, Yuling Zhou, Sijing Jiang*, Guimin Zhang*. High-level extracellular expression of a new β-N-acetylglucosaminidase in Escherichia coli for producing GlcNAc. Frontiers in microbiology, 2021

2. Chao Du(2020届硕士生), Xiang Zhao, Wen Song, Nisha He, Sijing Jiang, Yuling Zhou*, Guimin Zhang*. Combined strategies to improve the expression of acidic mammalian chitinase in Pichia pastoris for the production of N, N'-diacetylchitobiose. Biochemical Engineering Journal, 2021

3. Wen Song(2021届硕士生), Nuo Zhang, Mo Yang, Yuling Zhou, Nisha He*, Guimin Zhang*. Multiple strategies to improve the yield of chitinase A from Bacillus licheniformis in Pichia pastoris to obtain plant growth enhancer and GlcNAc. Microbial cell factory, 2020

4. Chuang Yan(2018届硕士生), Jingxuan Zhang, Pan Wu, Yong Gan, Guimin Zhang*. An EDTA-resistant pyrazinamidase from non-pathogen Pseudonocardia carboxydivorans. Biotechnol Lett, 2020

5. Pan Wu, Feifan Luo, Zhenghui Lu, Zhichun Zhan, Guimin Zhang*. Improving the catalytic performance of pectate lyase through pectate lyase/Cu3(PO4)2 hybrid nanoflowers as an immobilized enzyme. Frontiers in Bioengineering and Biotechnology, 2020, 8:280

6. Pan Wu, Shihui Yang, Zhichun Zhan, Guimin Zhang*. Origins and features of pectate lyases and their applications in industry, Applied Microbiology and biotechnology, 2020

7. Zhenghui Lu(2018届博士生), Xinzhi Li, Rui Zhang, Li Yi, Yanhe Ma, Guimin Zhang*. Tunnel engineering to accelerate product release for better biomass-degrading abilities in lignocellulolytic enzymes. Biotechnology for Biofuels, 2019

8. Xian Fan (2019届硕士生), Xinzhi Li, Yu Zhou, Meng Mei, Pi Liu, Jing Zhao, Wenfang Peng, Zhengbing Jiang, Shihui Yang, Brent L. Iverson, Guimin Zhang*, Li Yi*. Quantitative analysis of the substrate specificity of human rhinovirus 3C protease and exploration of its substrate recognition mechanisms, ACS Chemical Biology, 2019

9. Xinlin Hu (2020届硕士生), Xin Yuan, Nisha He, Pan Wu*, Guimin Zhang*. Expression of Bacillus licheniformis α-amylase in Pichia pastoris without antibiotics-resistant gene and effects of glycosylation on the enzymatic thermostability. 3 Biotech, 2019

10. La Xiang# (2016届硕士生), Yihong Lu#(2016届硕士生), Hui Wang, Meixing Wang, Guimin Zhang*. Improving the specific activity and pH stability of xylanase XynHBN188A by directed evolution. Bioresources and Bioprocessing, 2019

11. Chao Du (2020届硕士生), Shun Jiang, Sijing Jiang, Yuling Zhou*, Guimin Zhang*. A Bacillus pumilus originated β-N-acetylglucosaminidase for chitin combinatory hydrolysis and exploration of its thermostable mechanism. International Journal of Biological Macromolecules, 2019, 132: 1282-1289.

12. Yumeng Tang(2019届硕士生), Pan Wu, Sijing Jiang, Jonathan Nimal Selvaraj , Shihui Yang, Guimin Zhang*. A new cold-active and alkaline pectate lyase from Antarctic bacterium with high catalytic efficiency. Applied Microbiology and biotechnology, 2019, 103(13):5231-5241.

13. Zhenghui Lu(2018届博士生), Shihui Yang, Xin Yuan, Yunyun Shi, Li Ouyang, Sijing Jiang, Li Yi and Guimin Zhang*. CRISPR-assisted multi-dimensional regulation for fine-tuning gene expression in Bacillus subtilis. Nucleic Acids Research, 2019, 47(7): e401, doi: 10.1093/nar/gkz072.

15. Shun Jiang(2019届硕士生), Hongying Jiang, Yuling Zhou, Sijing Jiang*, Guimin Zhang*. High-level expression of β-N-Acetylglucosaminidase BsNagZ in Pichia pastoris to obtain GlcNAc. Bioprocess and Biosystems Engineering, 2019, https://doi.org/10.1007/s00449-018-02067-5.

16. Meixing Wang(2018届硕士生), Lifeng Yin, Huizhen Hu, Jonathan Nimal Selvaraj, Yuling Zhou, Guimin Zhang*. Expression, functional analysis and mutation of a novel neutral zearalenone-degrading enzyme, International Journal of Biological Macromolecules, 2018, 118(Pt A):1284-1292.

17. Yuling Zhou, Zhenghui Lu, Xiang Wang, Jonathan Nimal Selvaraj, Guimin Zhang*. Genetic engineering modification and fermentation optimization for extracellular production of recombinant proteins using Escherichia coli. Applied Microbiology and Biotechnology, 2018,102(4), 1545-1556.

18. Zhenghui Lu (2018届博士生), Xinlin Hu, Panpan Shen, Qinhong Wang, Yuling Zhou, Guimin Zhang*, Yanhe Ma. A pH-stable, detergent and chelator resistant type I pullulanase from Bacillus pseudofirmus 703 with high catalytic efficiency. International Journal of Biological Macromolecules, 2018

19. Xiaowen Wang (2017届硕士生)#, Zhenghui Lu(2018届博士生)#, Ting Xu, Jonathan Nimal Selvaraj, Li Yi, Guimin Zhang*. Improving the Specific Activity and Thermo-stability of Alkaline Pectate Lyase from Bacillus subtilis 168 for Bioscouring. Biochemical Engineering Journal, 2018,129:74-83.

20. Mei Meng (2017届硕士生), Zhai Chao, Li Xinzhi, Zhou Yu, Peng Wenfang, Ma Lixin, Wang Qinhong, Iverson BL, Zhang Guimin*, Yi Li*. Characterization of aromatic residue-controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae. Journal of Biological Chemistry. 2017, 292(50):20707-20719.

21. Cheng Fang (2014届硕士生), Qinhong Wang, Selvaraj JN, Yuling Zhou, Lixin Ma, Guimin Zhang*, Yanhe Ma. High copy and stable expression of the xylanase XynHB in Saccharomyces cerevisiae by rDNA-mediated integration. Scientific Reports, 2017, 7(1): 8747.

22. Shengchen Wang(2017届硕士生), Qinhong Wang, Yuling Zhou, Zhenghui Lu, Guimin Zhang*, Yanhe Ma. A new GH13 α-glucosidase from alkaliphilic Bacillus pseudofirmus 703 with both exo-α-l, 4-glucosidase and oligo-l, 6-glucosidase activities towards amylopectin. International Journal of Biological Macromolecules, 2017, 101: 973-982.

23. Meng Mei(2017届硕士生), Yu Zhou, Wenfang Peng, Chan Yu, Lixin Ma, Guimin Zhang*, Li Yi*. Application of Modified Yeast Surface Display Technologies for Non-Antibody Protein Engineering. Microbiological research, 2017, 196: 118-128.

24.李信志(2018届硕士生),卢争辉,周玉玲,李世宇,张桂敏*。枯草芽孢杆菌SCK6超级感受态的制备和转化条件优化,生物工程学报,2017334: 692-698

25.望潇文(2017届硕士生),向腊,徐婷,卢争辉,张桂敏*。碱性果胶酶高产菌株的构建和高密度发酵,生物工程学报,2017

26.    石云云(2019届硕士生),李信志,张桂敏*。微生物嗜盐酶的研究进展,微生物学报,2017

27.李顺意,于秋香,向腊,周玉玲,张桂敏*。真菌毒素玉米赤霉烯酮生物降解的研究进展,生物工程学报,2018

28.姜顺(2019届硕士生),郝少华,向腊,宋俐,周玉玲,蒋思婧*,张桂敏*。一种来源于兼性嗜碱菌Bacillus pseudofirmus 703β­N­乙酰氨基葡萄糖苷酶,微生物学报,2019


教师寄语:

持续努力,提高解决问题的能力


招生要求:  

勤于思考,执行力强