刘子鹤

发布时间:2019-10-31

  

姓名:刘子鹤

 

职称:见习教授

 

邮箱:zihe@mail.buct.edu.cn

 

办公地址:综合楼配楼104

 


  

教育背景:

2002.9-2006.6      天津大学化工学院,学士

2006.9-2008.6      天津大学化工学院,硕士

2008.9-2012.11    瑞典查尔摩斯大学,博士


工作经历: 

2021-至今:北京化工大学科学与技术学院   见习教授

2019-2020:北京化工大学科学与技术学院   生物工程系主任

2017-2021:北京化工大学科学与技术学院   副教授

2013-2017:新加坡科技研究局                       科学家I


主要研究领域:

实验室主要研究方向为代谢工程、系统生物学、合成生物学,具体包括:

1. 细胞机理

2. 细胞工厂

3. 系统与合成生物学工具的开发


获奖及荣誉:

2021    国家级青年人才

2019    北京化工大学青年英才百人计划


科研项目:

国家重点研发计划“合成生物学” 重点专项         课题负责人、子课题负责人

国家自然科学基金面上项目                                  主持

国家自然科学基金青年项目                                  主持

北京市自然科学基金面上项目                              主持


代表性著作:

1.    Liu Z, Wang K, Chen Y, Tan T#, Nielsen J#. Third-generation biorefineries as the means to produce fuels and chemicals from CO2. Nature Catalysis, 2020, 3: 274-288. (TOP)

2.    Zhang Y*, Wang J*, Wang Z, Zhang Y, Shi S, Nielsen J, Liu Z. A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae. Nature Communications, 2019, 10: 1053. (TOP)

3.    Gong G*, Zhang Y*, Wang Z, Liu L, Shi S, Siewers V, Yuan Q, Nielsen J, Zhang X#, Liu Z#. GTR 2.0: gRNA-tRNA array and Cas9-NG based genome disruption and dingle-nucleotide conversion in Saccharomyces cerevisiaeACS Synthetic Biology, 2021, DOI: 10.1021/acssynbio.0c00560. (TOP)

4.    Liu Z, Moradi H, Shi S#, Darvishi F#. Yeasts as microbial cell factories for sustainable production of biofuels. Renewable & Sustainable Energy Reviews, 2021, 143: 110907 (TOP)

5.    Zhao Y, Zhang Y, Nielsen J, Liu Z. Production of β-carotene in Saccharomyces cerevisiae through altering yeast lipid metabolism. Biotechnology and Bioengineering, 2021, 118: 2043-2052 (TOP)

6.    Liu Z, Lin Z, Nielsen J. Expression of fungal biosynthetic gene clusters in S. cerevisiae for natural product discovery. Synthetic and Systems Biotechnology, 2021. 6: 20-22.

7.    Zhang Y, Nielsen J#, Liu Z#. Yeast based biorefineries for oleochemical production. Current Opinion in Biotechnology, 2021. 67: 26-34. (TOP)

8.    李祎林振泉#, 刘子鹤#. 酿酒酵母适应性实验室进化工具的最新进展合成生物学, 2021. 2 (2): 287-301

9.    Zhang Y*, Su M*, Qin N, Nielsen J, Liu Z. Expressing a cytosolic pyruvate dehydrogenase complex to increase free fatty acid production in Saccharomyces cerevisiaeMicrobial Cell Factories, 2020, 19(1): 226.

10.  Qin N*, Li L*, Ji X, Li X, Zhang Y, Larsson C, Chen Y, Nielsen J, Liu Z. Rewiring central carbon metabolism ensures increased provision of acetyl-CoA and NADPH required for 3-OH-propionic acid production. ACS Synthetic Biology, 2020, 9: 3236-3244. (TOP)

11.  Lin Z, Nielsen J, Liu Z. Bioprospecting through cloning of whole natural product biosynthetic gene clusters. Frontiers in Bioengineering and Biotechnology, 2020, 8526.

12.  Liu Z, Zhang Y, Nielsen J. Synthetic biology of yeast. Biochemistry, 2019, 58: 1511-1520.

13.  Zhang Y, Nielsen J, Liu Z. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived hydrocarbons. Biotechnology and Bioengineering, 2018, 115 (9): 2139-2147. (TOP)


教师寄语:  

“As a scientist, you must constantly question yourself, your experiment and your data to find out what you might have overlooked, why the experiment did not work or why the results contradict you initial assumptions.”

Leonardo Almeida-Souza & Jonathan Baets


招生要求:

独立思考、勤奋好学、重诺守信