喻青松
姓名：喻青松 职称：见习教授 邮箱：yuqs@mail.buct.edu.cn 办公地址：化纤楼 104 个人主页：https://faculty.buct.edu.cn/life/yqs/main.htm |
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教育背景：
2004.9-2008.6 北京化工大学材料学院，工学学士（生物功能材料专业）
2008.9-2014.6 中国科学院化学研究所，理学博士（高分子化学与物理专业）
工作经历：
2014.7-2017.6 北京化工大学生命学院，博士后
2017.7-2024.03 北京化工大学生命学院，副教授
2024.03 –今 北京化工大学生命科学与技术学院，见习教授
主要研究领域：
1. 纳米药物纳米特性与递送过程生理屏障相关性；
2. 新型高效抗肿瘤纳米药物研发；
3. 纳米药物规模化制备及临床转化。
学术兼职：
《Exploration》青年编委、国家自然科学基金函评专家，教育部学位论文评审专家。
学术成绩：
主持国家自然科学基金优秀青年基金项目1项、面上项目3项、青年项目1 项，教育部联合基金1项，企业合作项目1项，并获得北京化工大学“青年英才百人计划”项目支持。
以第一/通讯作者在Adv. Mater.、Adv. Funct. Mater.、ACS Nano等国内外期刊发表学术论文30余篇，申请中国发明专利20项/PCT专利1项，授权中国发明专利11项。
代表性著作：
1.Yu, S.; Jiang, Y.; Li, Q.; Li, M.; Su, J.; Lai, S.; Gan, Z.; Ding, Z.*; Yu, Q.*, Nano-sensitizer with self-amplified drug release and hypoxia normalization properties potentiates efficient chemoradiotherapy of pancreatic cancer. Biomaterials 2024,310, 122634.
2.Yang, C.; Jiang, Y.; Zhang, K.; Zhu, X.; Li, J.; Yu, H.; Chen, J.; Gu, X.*; Gan, Z.; Yu, Q.*, Photodynamic Therapy Derived Personalized Whole Cell Tumor Vaccine Prevents Postsurgery Tumor Recurrence and Metastasis. Small 2024,20 (28), 2308456.
3.Li, J.; Yu, H.; Kang, Y.; Niu, K.; Wang, M.; Jiang, Y.; Jiang, N.; Ding, Z.*; Gan, Z.*; Yu, Q.*, STING Membrane Prevents Post-Surgery Tissue Adhesion and Tumor Recurrence of Colorectal Cancer. Advanced Materials 2024,36 (21), 2309655.
4.Hu, B.; Chen, J.; Gao, Z.; Chen, L.; Cao, T.; Li, H.; Yu, Q.*; Wang, C.; Gan, Z., Biodegradable MXene Quantum Dots with High Near-Infrared Photothermal Performance for Cancer Treatment. ACS Applied Bio Materials 2024,7 (7), 4339-4351.
5.Yang, C.; Guo, L.; Zhang, K.; Wang, G.; Yu, Q.*; Gan, Z.; Gu, X., Diradical-Featured Organic Small-Molecule Photothermal Material Based on 4,6-di(2-thienyl)thieno[3,4-c][1,2,5]thiadiazole for Photothermal Immunotherapy. Advanced Functional Materials 2023,33 (52), 2306360.
6.Liu, K.; Mo, Q.; Ding, Z.; Lai, S.; Ren, J.*; Yu, Q.*, Nano theranostics involved in bladder cancer treatment. Exploration of Drug Science 2023,1 (2), 81-106.
7.Gong, H.; Ding, Z.; Jiao, B.; Ren, J.*; Yu, Q.*, Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms. Advanced Sensor Research 2023,2 (9), 2300037.
8.Chen, J.-W.; Shen, Y.; Yu, Q.-S.*; Gan, Z.-H., Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy. Chinese Journal of Polymer Science 2023.
9.Zhu, X.; Li, L.; Tang, J.; Yang, C.; Yu, H.; Liu, K.; Zheng, Z.; Gu, X.*; Yu, Q.*; Xu, F.-J.; Gan, Z., Cascade-Responsive Nano-Assembly for Efficient Photothermal-Chemo Synergistic Inhibition of Tumor Metastasis by Targeting Cancer Stem Cells. Biomaterials 2022,280, 121305.
10.Zhang, P.; Ouyang, Q.; Zhai, T.; Sun, J.; Wu, J.; Qin, F.; Zhang, N.; Yue, S.; Yang, X.; Zhang, H.; Hou, Y.; Deng, L.; Wang, F.; Zhan, Q.*; Yu, Q.*; Qin, M.*; Gan, Z., An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy. Nanoscale 2022,14 (41), 15291-15304.
11.Zhang, L.; Du, X.; Li, Q.; Qian, L.; Chen, J.; Liu, C.; Yu, Q.*; Gan, Z*., A Multimodal Therapeutic Nanoplatform Overcoming Tumor Hypoxia Heterogeneity for Improved Tumor Chemoradiotherapy. Advanced Functional Materials 2022,32 (34), 2204629.
12.Tang, X.; Du, X.; Yu, Y.; Qin, M.; Qian, L.; Zhang, M.; Yang, Y.; Yu, Q.*; Gan, Z.*, Deep-Penetrating Triple-Responsive Prodrug Nanosensitizer Actuates Efficient Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma Models. Small 2022,18 (31), 2202834.
13.Qian, L.; Li, Q.; Ding, Z.; Luo, K.; Su, J.; Chen, J.; Zhu, G.*; Gan, Z.; Yu, Q.*, Prodrug Nanosensitizer Overcomes the Radiation Resistance of Hypoxic Tumor. ACS Applied Materials & Interfaces 2022,14 (51), 56454-56470.
14.Li, Y.; Jiang, Y.; Zheng, Z.; Du, N.; Guan, S.; Guo, W.; Tang, X.; Cui, J.; Zhang, L.; Liu, K.*; Yu, Q.*; Gan, Z., Co-Delivery of Precisely Prescribed Multi-Prodrug Combination by an Engineered Nanocarrier Enables Efficient Individualized Cancer Chemotherapy. Advanced Materials 2022,34 (12), 2110490.
15.Jiao, B.; Liu, K.; Gong, H.; Ding, Z.; Xu, X.; Ren, J.; Zhang, G.*; Yu, Q.*; Gan, Z.*, Bladder cancer selective chemotherapy with potent NQO1 substrate co-loaded prodrug nanoparticles. Journal of Controlled Release 2022,347, 632-648.
16.Yu, Y.; Xiang, K.; Xu, M.; Li, Y.; Cui, J.; Zhang, L.; Tang, X.; Zhu, X.; Qian, L.; Zhang, M.; Yang, Y.; Yu, Q.*; Shen, Y.; Gan, Z., Prodrug Nanomedicine Inhibits Chemotherapy-Induced Proliferative Burst by Altering the Deleterious Intercellular Communication. ACS Nano 2021,15, 781-796.
17.Shi, R.; Zhang, J.; Niu, K.; Li, W.; Jiang, N.; Li, J.; Yu, Q.; Wu, C., Electrospun Artificial Periosteum Loaded with DFO Contributes to Osteogenesis via the TGF-β1/Smad2 Pathway. Biomaterials Science 2021,9, 2090-2102.
18.Xu, X.; Liu, K.; Jiao, B.; Luo, K.; Ren, J.; Zhang, G.*; Yu, Q.*; Gan, Z.*, Mucoadhesive Nanoparticles based on ROS Activated Gambogic Acid Prodrug for Safe and Efficient Intravesical Instillation Chemotherapy of Bladder Cancer. Journal of Controlled Release 2020,324, 493-504.
19.Qin, M.; Cao, Z.; Wen, J.; Yu, Q.; Liu, C.; Wang, F.; Zhang, J.; Yang, F.; Li, Y.; Fishbein, G.; Yan, S.; Xu, B.; Hou, Y.; Ning, Z.; Nie, K.; Jiang, N.; Liu, Z.; Wu, J.; Yu, Y.; Li, H.; Zheng, H.; Li, J.; Jin, W.; Pang, S.; Wang, S.; Chen, J.; Gan, Z.; He, Z.; Lu, Y., An Antioxidant Enzyme Therapeutic for COVID-19. Advanced Materials 2020,32.
20.Luo, K.; Guo, W.; Yu, Y.; Xu, S.; Zhou, M.; Xiang, K.; Niu, K.; Zhu, X.; Zhu, G.; An, Z.; Yu, Q.*; Gan, Z.*, Reduction-Sensitive Platinum (IV)-Prodrug Nano-Sensitizer with an Ultra-High Drug Loading for Efficient Chemo-Radiotherapy of Pt-Resistant Cervical Cancer in vivo. Journal of Controlled Release 2020,326, 25-37.
21.Zhou, Q.; Shao, S.; Wang, J.; Xu, C.; Xiang, J.; Piao, Y.; Zhou, Z.; Yu, Q.; Tang, J.; Liu, X.; Gan, Z.; Mo, R.; Gu, Z.; Shen, Y., Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy. Nature Nanotechnology 2019,14, 799-809.
22.Zhang, Y.; Fang, Q.; Niu, K.; Gan, Z.; Yu, Q.*; Gu, T.*, Time-Dependently Slow-Released Multiple-Drug Eluting External Sheath for Efficient Long-Term Inhibition of Saphenous Vein Graft Failure. Journal of Controlled Release 2019,293, 172-182.
23.Zhang, X.; He, F.; Xiang, K.; Zhang, J.; Xu, M.; Long, P.; Su, H.; Gan, Z.*; Yu, Q.*, CD44-Targeted Facile Enzymatic Activatable Chitosan Nanoparticles for Efficient Antitumor Therapy and Reversal of Multidrug Resistance. Biomacromolecules 2018,19, 883-895.
24.Zhang, J.; Tang, H.; Shen, Y.; Yu, Q.*; Gan, Z.*, Shell-Sheddable Poly(N-2-Hydroxypropyl methacrylamide) Polymeric Micelles for Dual-Sensitive Release of Doxorubicin. Macromolecular Rapid Communications 2018,39, 1800139.
25.Tang, H.; Zhang, J.; Tang, J.; Shen, Y.; Guo, W.; Zhou, M.; Wang, R.; Jiang, N.; Gan, Z.*; Yu, Q.*, Tumor Specific and Renal Excretable Star-like Triblock Polymer-Doxorubicin Conjugates for Safe and Efficient Anticancer Therapy. Biomacromolecules 2018,19, 2849-2862.
26.Yan, X.; Yu, Q.*; Guo, L.; Guo, W.; Guan, S.; Tang, H.; Lin, S.; Gan, Z.*, Positively Charged Combinatory Drug Delivery Systems against Multi-Drug-Resistant Breast Cancer: Beyond the Drug Combination. ACS Applied Materials & Interfaces 2017,9, 6804-6815.
27.Shen, T.; Xu, X.; Guo, L.; Tang, H.; Diao, T.; Gan, Z.; Zhang, G.*; Yu, Q.*, Efficient Tumor Accumulation, Penetration and Tumor Growth Inhibition Achieved by Polymer Therapeutics: The Effect of Polymer Architectures. Biomacromolecules 2017,18, 217-230.
28.Shen, T.; Guan, S.; Gan, Z.; Zhang, G.*; Yu, Q.*, Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation. Biomacromolecules 2016,17, 1801-1810.
29.Du, N.; Guo, W.; Yu, Q.*; Guan, S.; Guo, L.; Shen, T.; Tang, H.; Gan, Z.*, Poly(D,L-Lactic Acid)-block-poly(N-(2-Hydroxypropyl) methacrylamide) Nanoparticles for Overcoming Accelerated Blood Clearance and Achieving Efficient Anti-Tumor Therapy. Polymer Chemistry 2016,7, 5719-5729.
30.Yu, Q.; Zhang, J.; Zhang, G.; Gan, Z., Synthesis and Functions of Well-Defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer. Macromolecular Bioscience 2015,15, 509-520.
31.Yu, Q.; Wei, Z.; Shi, J.; Guan, S.; Du, N.; Shen, T.; Tang, H.; Jia, B.; Wang, F.; Gan, Z., Polymer-Doxorubicin Conjugate Micelles Based on Poly(Ethylene Glycol) and Poly(N-(2-Hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules 2015,16, 2645-2655.
32.Yu, Q.; Dong, C.; Zhang, J.; Shi, J.; Jia, B.; Wang, F.; Gan, Z., Synthesis of Poly(Ethylene Glycol)-b-Poly(N-(2-Hydroxypropyl) methacrylamide) Block Copolymers with Well-Defined Structures and Their Influence on in vivo Circulation and Biodistribution. Polymer Chemistry 2014,5, 5617-5627.
教师寄语:
希望肿瘤能被我们这一代人攻克，加入我们与我们一起改变人类的未来。
招生要求：
专业不限，但是要刻苦、刻苦、刻苦！