林白雪

林白雪

教育背景：

2006.09–2010.06    福建农林大学，生化与分子生物学专业，博士学位

2000.09–2003.06    华南理工大学，发酵工程专业，硕士学位

1996.09–2000.06    华南理工大学，制药工程专业（辅修英语），学士学位

工作经历：

2025.07-至今        北京化工大学生命科学与技术学院，教授

2021.11–2025.06     中国科学院微生物研究所，研究员

2016.08–2016.11     University of Delaware，访问学者

2015.09–2021.10     中国科学院微生物研究所，副研究员

2013.04–2015.09     中国科学院微生物研究所，助理研究员

2010.09–2013.03     中国科学院微生物研究所，博士后

2003.07–2010.09     福建农林大学，助理研究员

主要研究领域：

代谢工程和合成生物学

课题组围绕微生物细胞工厂的构建与优化，聚焦生物合成过程中的关键性问题，结合代谢工程与合成生物学手段，提升细胞工厂的合成效率，实现高附加值化学品的高效、绿色生物制造。

学术兼职：

Metabolic engineering, Chemical Engineering Journal、Journal of Agricultural and Food Chemistry、ACS Sustainable Chemistry & Engineering、Biotechnology and Bioengineering、Enzyme and Microbial Technology、Synthetic and Systems Biotechnology等期刊审稿专家。

学术成绩：

主持国家自然科学基金面上项目、国家重点研发计划子课题、省自然科学基金、中国博士后基金以及多项企业合作重大项目等。

在Nature Communications、PNAS、Metabolic Engineering等国际主流期刊发表SCI论文34篇，参编中英文专著2部。申请国家发明专利28项，已授权18项，十余项技术成果已实现转让和产业化应用。

获奖及荣誉：

中国轻工业联合会科技进步奖二等奖

中国科学院微生物十大科研进展

中国科学院特聘研究骨干

代表性著作：

1. Hang Zhou, Yiwen Zhang, Christopher P. Long, Xuesen Xia, Yanfen Xue, Yanhe Ma^*, Maciek R. Antoniewicz^*, Yong Tao^*, Baixue Lin*. A citric acid cycle-deficient Escherichia coli as an efficient chassis for aerobic fermentations. Nature Communications. 2024 ,15(1): 2372.

2. Baixue Lin, Keqiang Fan, Jian Zhao, Junjie Ji, Linjun Wu, Keqian Yang*, Yong Tao*. Reconstitution of TCA

   cycle with DAOCS to engineer E. coli into an efficient whole cell catalyst of penicillin G. Proc Natl Acad Sci

   U S A 2015,112(32):9855-9

3. Congrong Shi, Xiaojing Huo, Ran You, Yong Tao, Baixue Lin*. High yield production of L-isoleucine

   through readjusting the ratio of two direct precursors in Escherichia coli.Bioresource Technology. 2025,

   418:131889.

4. Qun Liu, Baixue Lin*, Yong Tao*. Improved methylation in E. coli via an efficient methyl supply system driven by betaine. Metabolic Engineering. 2022, 72: 46-55.

5. Pengchao Wang, Xinwei Yang, Baixue Lin*, Jianzhong Huang*, Yong Tao*. Cofactor self-sufficient whole-

   cell biocatalysts for the production of 2-phenylethanol. Metabolic Engineering, 2017,44:143-149.  

6. Quanxiu Gao, Hao Chen, Gaoyan Wang, Wei Yang, Xiaotong Zhong, Jiezheng Liu, XiaoJing Huo, Weifeng

   Liu, Jianzhong Huang*, Yong Tao*, Baixue Lin*. Highly Efficient Production of Menaquinone‑7 from

   Glucose by Metabolically Engineered Escherichia coli. ACS Synthetic Biology. 2021, 10(4): 756–765.

7. Zhanhui Wang^#, Baixue Lin^#, Siyu Sheng, Sicong Tan, Pengchao Wang, Yong Tao, Zhang Liu, Zhiyuan

   He*,Jianjun Wang. Bioinspired Anti-Icing Hydrogel Enabled by Ice-Nucleating Protein. CCS Chem. 2021,

   3:473–480  

8. Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu, Xiaotong Zhong, Quanxiu Gao, Jiezheng Liu, Jianzhong

   Huang*, Baixue Lin*, Yong Tao. Metabolic engineering of Escherichia coli for efficient production of L-

   alanyl-L-glutamine. Microbial Cell Factories.2020,19(1):129.

9. Yiwen Zhang, Hang Zhou, Yong Tao*, Baixue Lin*. Reconstitution of the Ornithine Cycle with

   Arginine:Glycine Amidinotransferase to Engineer Escherichia coli into an Efficient Whole-Cell Catalyst of

   Guanidinoacetate. ACS Synthetic Biology. 2020,9(8):2066-2075.

10. Jing Feng, Ruifeng Li, Shasha Zhang, Yifan Bu, Yanchun Chen, Yinglu Cui, Baixue Lin, Yihua Chen, Yong

    Tao, Bian Wu*. Bioretrosynthesis of Functionalized N-Heterocycles from Glucose via One-Pot Tandem

    Collaborations of Designed Microbes. Advanced Science, 2020, 7(17): 2001188.  

11. Quanxiu Gao, Hao Chen, Wenzhao Wang, Jianzhong Huang, Yong Tao, Baixue Lin*. Menaquinone-7

    production in engineered Escherichia coli. World Journal of Microbiology and Biotechnology.2020,

    36:132.  

12. Xiaoyu Piao, Lei Wang, Baixue Lin, Hao Chen, Weifeng Liu*, Tao Yong*. Metabolic engineering of

    Escherichia coli for production of L-aspartate and its derivative beta-alanine with high stoichiometric

    yield. Metabolic engineering. 2019, 54:244-254

13. Shasha Zhang, Wei Yang, Hao Chen, Bo Liu, Baixue Lin*, Yong Tao*. Metabolic engineering for efficient

    supply of acetyl-CoA from different carbon sources in Escherichia coli. Microbial Cell Factories.

    2019,18:130.

14. Baixue Lin*, Yong Tao*. Whole-cell biocatalysts by design. Microbial Cell Factories, 2017, 16:106.  

15. Xun Lv, Hongzhi Cao, Baixue Lin*, Wei Wang, Wande Zhang, Qian Duan, Yong Tao, Xue-Wei Liu, Xuebing

    Li*. Synthesis of sialic acids, their derivatives and analogues using a whole-cell catalyst. Chemistry - A

    European Journal, 2017,23(26): 15143–15149.  

16. Baixue Lin*, Yu Qiao, Bo Shi, Yong Tao. Polysialic acid biosynthesis and production in Escherichia coli:

    Current state and perspectives. Applied Microbiology and Biotechnology, 2016,100(1):1-8.  

17. Keqiang Fan, Baixue Lin, Yong Tao, Keqian Yang*. Engineering deacetoxycephalosporin C synthase as a

    catalyst for the bioconversion of penicillins. Journal of Industrial Microbiology & Biotechnology.

    2016,44(4): 705-710.  

18. Fang Chen, Yong Tao, Cheng Jin, Yang Xu, Baixue Lin*. Enhanced production of polysialic acid by metabolic engineering of Escherichia coli. Applied Microbiology and Biotechnology, 2015,99:2603-2611.  

19. Baixue Lin, Zijuan Zhang, Weifeng Liu, Zhiyang Dong, Yong Tao*. Enhanced production of N-acetyl-D-

    neuraminic acid by multi-approach whole-cell biocatalyst. Applied Microbiology and Biotechnology,

    2013,97: 4775-84.  

教师寄语:

Be your personal best ——做最好的自己，在科研与人生中不断成长与超越。

招生要求：

热爱科研，勤奋认真，善于思考。