耿文超

耿文超

教育背景：

2010年9月-2014年6月，南京航空航天大学材料科学与技术学院，学士（应用化学）

2014年9月-2017年6月，南开大学化学学院，硕士（物理化学）

2017年9月-2020年6月，南开大学化学学院，博士（物理化学）

2018年11月-2019年11月，美国德克萨斯大学奥斯汀分校，联合培养（有机化学）

工作经历：

2020年10月-2021年3月，中国科学院微生物研究所，研究实习员

2021年3月-2022年12月，中国科学院天津工业生物技术研究所，博士后(生物学)

2022年12月-2025年1月，南开大学化学学院，讲师

2025年2月至今，北京化工大学生命科学与技术学院，副教授

主要研究领域：

合成生物学、超分子化学，具体包括：

1. 金属酶催化反应及合成生物学应用

2. 分子识别受体设计及疾病诊疗应用

3. 合成生物构建人工超分子化学体系

科研项目：

1. 高效分子识别的环肽主体设计，2025.01.01至2028.12.31，国家自然科学基金委员会，面上项目，22471137，50万元，主持

2. 基于两亲杯芳烃组装体能量转移平台的生物分子荧光成像，2023.01.01至2024.12.31，国家自然科学基金委员会，青年科学基金项目，22201299，20万元，主持

3. 基于人工智能的功能蛋白质设计和优化，2024.12至2027.11，国家重点研发计划，“前沿生物技术”重点专项，2024YFC3405500，1425万元，参与（项目骨干）

4. 聚对苯二甲酸乙二酯(PET)塑料降解互补酶MHETase的机制解析及改造应用，2022.01.01至2025.12.31，国家自然科学基金委员会，面上项目，32170033，58万元，参与

5. 减负增效超分子抗肿瘤纳米药物，2019.07.01至2022.06.30，国家自然科学基金委员会，国际(地区)合作与交流项目，31961143004，175万元，参与

6. 两亲杯芳烃自组装生物医用纳米材料，2019.01.01至2022.12.31，国家自然科学基金委员会，面上项目，51873090，59万元，参与

7. 两亲杯芳烃组装体界面多价键合用于生物大分子荧光传感，2017.01.01至2020.12.31，国家自然科学基金委员会，面上项目，21672112，65万元，参与

学术兼职：

Molecules杂志青年编委和专刊编辑，ACS Nano、Sci. China Mater.、Biosens. Bioelectron.、大学化学、J. Drug Deliv. Sci. Technol.、D. Pigment.等期刊审稿人。

学术成绩：

主持国家自然科学基金面上项目、青年项目各1项，中央高校基本科研业务费1项。已发表SCI论文45篇，以第一/通讯作者身份在Chem. Soc. Rev.、Angew. Chem. Int. Ed. (3)、ACS Nano、Chem. Sci.等权威期刊发表论文20篇，H因子25，累计引用2000余次。

科研论文：

1. Zhe Zheng, Hanyu Lv, Ruina Liu, Wen-Chao Geng*, Chunju Li*, Internal cavity versus external cavity: a theoretical study of molecular recognition of biphenarene. J. Phys. Chem. A, 2025, 129, 5799-5809.

2. Shun-Yu Yao^#, An-Kang Ying^#, Wen-Chao Geng, Fang-Yuan Chen, Xin-Yue Hu, Kang Cai*, Dong-Sheng Guo*, High-affinity 1:2 recognition based on naphthyl-azocalix[4]arene and its application as a cleavable noncovalent connector in constructing responsive supramolecular polymeric materials. Chem. Sci., 2025, 16(16), 7066-7076.

3. Lianzhu Wei, Ling Chen, Yuanyong Li, Maocheng Yang, Mingyan Yang, Wen‐Chao Geng, Zeli Yuan, Jie Gao*, A Chemiluminescent hydrogen sulfide probe with multimodal validation for inflammation diagnosis in vivo. Chem. Asian J., 2025, 20, e202401909.

4.  Fang-Yuan Chen, Wen-Chao Geng, Meng-Meng Chen, Rong Fu, Han Han, Zhan-Zhan Zhang, Wen-Bo Li, Yuan-Qiu Cheng, Juan-Juan Li, J Fraser Stoddart*, Kang Cai*, Dong-Sheng Guo*, Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities. Proc. Natl. Acad. Sci. U.S.A., 2025, 122(3), e2414253122.

5. Ai-Feng Liu^#, Shihui Li^#, Fang-Yuan Chen, Jun-Tao Zhang, Fang-Xing Zeng, Hui-Chuan Feng, Ping Wang, Wen-Chao Geng*, Chuan-Rui Ma*, Dong-Sheng Guo*, A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chin. Chem. Lett., 2025, 36, 109752.

6. Jie Gao, Shangli Ding, Ling Chen, Hongyu Li, Wen-Chao Geng*, Dong-Sheng Guo*, Zeli Yuan*. Supramolecular photothermal agents mediated by black hole hosts, Nano Today, 2024, 59, 102520.

7. Fang-Yuan Chen, Cheng-Zhi Li, Han Han, Wen-Chao Geng, Shu-Xin Zhang, Ze-Tao Jiang, Qing-Yu Zhao, Kang Cai*, Dong-Sheng Guo*, Expanding the Hydrophobic Cavity Surface of Azocalix[4]arene to Enable Biotin/Avidin Affinity with Controlled Release. Angew. Chem. Int. Ed., 2024, 63(23), e202402139.

8. Shun-Yu Yao, An-Kang Ying, Ze-Tao Jiang, Yuan-Qiu Cheng, Wen-Chao Geng, Xin-Yue Hu, Kang Cai*, Dong-Sheng Guo*, Single molecular nanomedicines based on macrocyclic carrier-drug conjugates for concentration-independent encapsulation and precise activation of drugs. J. Am. Chem. Soc., 2024, 146(20), 14203-14212.

9. Meng-Meng Chen, Yuqiao Li, Yujie Zhu, Wen-Chao Geng*, Fang-Yuan Chen, Juan-Juan Li, Ze-Han Wang, Xin-Yue Hu, Qiong Tang, Yang Yu*, Tianwei Sun*, and Dong-Sheng Guo*. Supramolecular 3 in 1: A lubrication and co-Delivery system for synergistic advanced osteoarthritis therapy. ACS Nano 2024, 18, 13117-13129.

10. Wen-Chao Geng, Ze-Tao Jiang, Shi-Lin Chen, Dong-Sheng Guo*. Supramolecular interaction in the action of drug delivery systems, Chem. Sci., 2024, 15, 7811-7823.

11. Meng-Meng Chen^#, Xingchen Tang^#, Juan-Juan Li^#, Fang-Yuan Chen, Ze-Tao Jiang, Rong Fu, Hua-Bin Li, Xin-Yue Hu, Wen-Chao Geng*, Dong-Sheng Guo*. Active targeting tumor therapy using host-guest drug delivery system based on biotin functionalized azocalix[4]arene. J. Control. Release, 2024, 368, 691-702.

12. Fang-Yuan Chen, Wen-Chao Geng, Kang Cai*, Dong-Sheng Guo*. Molecular recognition of cyclophanes in water. Chin. Chem. Lett., 2024, 35(5), 109161.

13. 刘欣悦, 耿文超, 孙瑨原, 陈泽华, 崔颖璐*, 吴边*. 基于结构信息的MHET降解酶挖掘及温和温度下的酶级联塑料降解. 生物工程学报, 2024, 40(3): 773-785. Xinyue Liu, Wenchao Geng, Jinyuan Sun, Zehua Chen, Yinglu Cui, Bian Wu. Structure motif guided mining of MHET hydrolase and development of a two-enzyme cascade for plastics depolymerization at mild temperature. Chinese Journal of Biotechnology, 2024, 40(3): 773-785.

14. Yinglu Cui*^#, Yanchun Chen^#, Jinyuan Sun^#, Tong Zhu^#, Hua Pang, Chunli Li, Wen-Chao Geng, Bian Wu*. Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading. Nat. Commun. 2024, 15(1), 1417.

15. Rong Fu, Qing‐Yu Zhao, Han Han, Wen‐Li Li, Fang‐Yuan Chen, Chun Tang, Wei Zhang, Si‐Dan Guo, Dai‐Yuan Li, Wen‐Chao Geng, Dong‐Sheng Guo*, Kang Cai*. A Chiral Emissive Conjugated Corral for High-Affinity and Highly Enantioselective Recognition in Water. Angew. Chem. Int. Ed., 2023, 62(51), e202315990.

16. 阮文娟, 李悦, 耿文超, 郭东升*, 当表面活性剂遇到大环分子. 大学化学, 2023, 38(12), 114-119. Wen-Juan Ruan, Yue Li, Wen-Chao Geng, Dong-Sheng Guo*, Encountering of Surfactants with Macrocyclic Molecules. Univ. Chem. 2023, 38(12), 114-119.

17. Shihui Li^#, Juan-Juan Li^#, Ying-Ying Zhao, Meng-Meng Chen, Shan-Shan Su, Shun-Yu Yao, Ze-Han Wang, Xin-Yue Hu, Wen-Chao Geng, Wei Wang*, Ke-Rang Wang*, Dong-Sheng Guo*. Supramolecular Integration of Multifunctional Nanomaterial by Mannose-Decorated Azocalixarene with Ginsenoside Rb1 for Synergistic Therapy of Rheumatoid Arthritis. ACS Nano 2023, 17(24), 25468-25482.

18. Hongmei Yu, Shihui Li, Hanwen Tian, Yilin Lin, Shuxin Zhang, Wenchao Geng, Huabin Li, Honglei Wang, Juan Liu, Dongsheng Guo*. Enhancement of Solubility, Stability and Permeation of Skin-care Ingredients by Amphiphilic Sulfonated Calix [8] arene. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2023, 44(10), 0251-0790.

19. Wen-Chao Geng, Zhe Zheng, Huifeng Jiang* and Dong-Sheng Guo*, Nucleotide recognition by a guanidinocalixarene receptor in aqueous solution. Chemical Research in Chinese Universities, 2023, 39, 144-150.

20. Siying Ren^#, Wen-Chao Geng^#, Xuexian Cui, Bian Wu* and Zhe Zheng*, A label-free and continuous fluorescence detection for L-DOPA decarboxylase activity based on supramolecular tandem assay. ChemistrySelect, 2023, 8, e202203646.

21. Xuexian Cui^#, Wen-Chao Geng^#, Huifeng Jiang* and Bian Wu*, Photobiocatalytic cascades for acylating N-heterocycles with natural amino acids via the 2-keto acids. Advanced Synthesis & Catalysis, 2022, 364, 4013-4019.

22. Shihui Li, Rong Ma, Xin-Yue Hu, Hua-Bin Li, Wen-Chao Geng, Xianglei Kong, Chao Zhang, and Dong-Sheng Guo*. Drug in Drug: A Host–Guest Formulation of Azocalixarene with Hydroxychloroquine for Synergistic Anti-Inflammation. Advanced Materials 34(32), 2022, 2203765.

23. Tong Zhu, Yinglu Cui, Wenchao Geng, Guoxia Liu, Huifeng Jiang, Ruifeng Li, and Bian Wu*. Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C-Terminal Traceless Functionalization. ACS Catalysis, 2022, 12(13), 8019–26.

24. Yaping Zhang, Huijuan Yu, Shiwei Chai, Xin Chai, Luyao Wang, Wen-Chao Geng, Juan-Juan Li,Yu-Xin Yue,Dong-Sheng Guo*,Yuefei Wang*. Noninvasive and Individual-Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing. Advanced Science, 2022, 9(18), 2104463.

25. Zhe Zheng, Siying Ren, Wen-Chao Geng, Xuexian Cui, Bian Wu*, and Hong Wang*. Monitoring Methionine Decarboxylase by a Supramolecular Tandem Assay. Chemistry – An Asian Journal, 2022, 17(10), e202200106.

26. Jing Feng^#, Wen-Chao Geng^#, Huifeng Jiang, Bian Wu*, Recent advances in biocatalysis of nitrogen-containing heterocycles, Biotechnol. Adv., 2022, 54, 107813

27. Yuan-Qiu Cheng^#, Yu-Xin Yue^#, Hong-Mei Cao^#, Wen-Chao Geng, Lan-Xing Wang, Xin-Yue Hu, Hua-Bin Li, Qiang Bian, Xiang-Lei Kong, Jian-Feng Liu, De-Ling Kong, Dong-Sheng Guo* and Yue-Bing Wang*, Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy. Journal of Nanobiotechnology, 2021, 19, 451.

28. Huijuan Yu, Xin Chai, Wen-Chao Geng, Lei Zhang, Fei Ding, Dong-Sheng Guo* and Yuefei Wang*, Facile and label-free fluorescence strategy for evaluating the influence of bioactive ingredients on FMO3 activity via supramolecular host-guest reporter pair. Biosens. Bioelectron., 2021, 192, 113488

29. Zhanzhan Zhang^#, Yu-Xin Yue^#, Lina Xu, Ying Wang, Wen-Chao Geng, Juan-Juan Li, Xiang-lei Kong, Xinzhi Zhao, Yadan Zheng, Yu Zhao, Linqi Shi*, Dong-Sheng Guo* and Yang Liu*, Macrocyclic-amphiphile-based self-assembled nanoparticles for ratiometric delivery of therapeutic combinations to tumors. Adv. Mater., 2021, 33, 2007719.

30. Wen-Chao Geng^#, Zhongju Ye^#, Zhe Zheng, Jie Gao, Juan-Juan Li, Muhammad Raza Shah, Lehui Xiao*, Dong-Sheng Guo*. Supramolecular Bioimaging through Signal Amplification by Combining Indicator Displacement Assay with Förster Resonance Energy Transfer. Angew. Chem. Int. Ed., 2021, 60, 19614-19619.

31. Zhe Zheng, Wen-Chao Geng, Hua-Bin Li and Dong-Sheng Guo*, Sensitive fluorescence detection of saliva pepsin by a supramolecular tandem assay enables the diagnosis of gastroesophageal reflux disease. Supramol. Chem., 2021, 33, 80-87.

32. Wen-Chao Geng^#, Dongmei Zhang^#, Chu Gong, Zhihao Li, Kevin M. Barraza, Jesse L. Beauchamp, Dong-Sheng Guo*, Xinxing Zhang*. Host-guest complexation of amphiphilic molecules at the air-water interface prevents oxidation by hydroxyl radicals and singlet oxygen, Angew. Chem. Int. Ed., 2020, 59, 12684-12688.

33. Wen-Chao Geng, Jonathan L. Sessler*, Dong-Sheng Guo*, Supramolecular prodrugs based on host–guest interactions, Chem. Soc. Rev., 2020, 49, 2303-2315.

34. Wen-Chao Geng, Zhe Zheng and Dong-Sheng Guo*, Supramolecular design based activatable magnetic resonance imaging. VIEW, 2020, 20200059.

35. Miao Guo, Wen-Chao Geng, Chengbin Liu*, Jiayun Gu, Zezhong Zhang, and Yanhong Tang*, Ultrahigh areal capacitance of flexible MXene electrodes: electrostatic and steric effects of terminations. Chem. Mater., 2020, 32, 8257-8265.

36. Zhe Zheng, Huijuan Yu, Wen-Chao Geng, Xin-Yue Hu, Yu-Ying Wang, Zhihao Li, Yuefei Wang and Dong-Sheng Guo*, Guanidinocalix[5]arene for sensitive fluorescence detection and magnetic removal of perfluorinated pollutants. Nat. Commun., 2019, 10, 5762.

37. Yu-Ying Wang, Yong Kong, Zhe Zheng, Wen-Chao Geng, Zi-Yi Zhao, Hongwei Sun and Dong-Sheng Guo*, Complexation of a guanidinium-modified calixarene with diverse dyes and investigation of the corresponding photophysical response. Beilstein J. Org. Chem., 2019, 15, 1394-1406.

38. Wen-Chao Geng^#, Shaorui Jia^#, Zhe Zheng, Zhihao Li, Dan Ding*, Dong-Sheng Guo*. A noncovalent fluorescence turn-on strategy for hypoxia imaging, Angew. Chem. Int. Ed., 2019, 58, 2377-2381.

39. Huijuan Yu, Wen-Chao Geng, Zhe Zheng, Jie Gao, Dong-Sheng Guo* and Yuefei Wang*, Facile fluorescence monitoring of gut microbial metabolite trimethylamine N-oxide via molecular recognition of guanidinium-modified calixarene. Theranostics, 2019, 9, 4624-4632.

40. Zhe Zheng, Wen-Chao Geng, Zhe Xu and Dong-Sheng Guo*, Macrocyclic amphiphiles for drug delivery. Isr. J. Chem., 2019, 59, 913-927.

41. Wen-Chao Geng, Qiaoxian Huang, Zhe Xu, Ruibing Wang* and Dong-Sheng Guo*, Gene delivery based on macrocyclic amphiphilies. Theranostics, 2019, 9, 3094-3106.

42. Wen-Chao Geng, Hongwei Sun and Dong-Sheng Guo*, Macrocycles containing azo groups: recognition, assembly and application. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2018, 92, 1-79.

43. Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen, Xingchen Duan, Zhe Zheng, Dan Ding* and Dong-Sheng Guo*, Biomarker Displacement Activation: a General Host-Guest Strategy for Targeted Phototheranostics in Vivo. J. Am. Chem. Soc., 2018, 140, 4945-4953.

44. Zhe Zheng, Wen-Chao Geng, Jie Gao, Yi-Jiang Mu and Dong-Sheng Guo*, Differential calixarene receptors create patterns that discriminate glycosaminoglycans. Org. Chem. Front., 2018, 5, 2685-2691.

45. Zhe Zheng, Wen-Chao Geng, Jie Gao, Yu-Ying Wang, Hongwei Sun and Dong-Sheng Guo*. Ultrasensitive and Specific Fluorescence Detection of a Cancer Biomarker via Nanomolar Binding to a Guanidinium-Modified Calixarene. Chem. Sci. 2018, 9, 2087-2091.

46. Wen-Chao Geng, Yan-Cen Liu, Zhe Zheng, Dan Ding and Dong-Sheng Guo*, Direct visualization and real-time monitoring of dissipative self-assembly by synchronously coupled aggregation-induced emission. Materials Chemistry Frontiers, 2017, 1, 2651-2655.

47. Wen-Chao Geng, Yan-Cen Liu, Yu-Ying Wang, Zhe Xu, Zhe Zheng, Cheng-Bo Yang and Dong-Sheng Guo*, A self-assembled white-light-emitting system in aqueous medium based on a macrocyclic amphiphile. Chemical Communications, 2017, 53, 392-395.

教师寄语:

当不负大时代。

招生要求：

勇于探索。