季宇

发布时间：2024-08-23

季宇

姓名：季宇

职称：副教授

邮箱：yuji@mail.buct.edu.cn

办公地址：高精尖大厦801


教育背景：

2008.09-2012.07   北京化工大学   理学 学士

2012.09-2015.06   北京化工大学   理学 硕士

2015.09-2020.05   德国亚琛工业大学 自然科学 博士

工作经历：

2020.01–2020.05       德国亚琛工业大学生物技术研究所，博士后

2020.05–2024.05          德国亚琛工业大学生物技术研究所，研究组组长

2023.05-2024.05        德国SeSaM生物技术公司，首席科学家（兼职）

2024.06–今      北京化工大学生命科学与技术学院，副教授


主要研究领域：

蛋白质工程，酶催化


学术兼职：

德国生物经济科学中心(BioSC)成员，Bioresources and Bioprocessing期刊客座编辑


学术成绩：

主持德国德国科学基金会（DFG）项目1项， 德国联邦教育与研究部（BMBF）项目5项，欧盟委员会（EU）项目子课题1项，德国生物经济科学中心项目1项。

以第一/通讯作者在Angew. Chem.，Int. Ed.，ACS Catal.，Adv. Sci.，Green Chem.等期刊发表SCI论文20余篇,并应邀在国际知名丛书：酶学方法 (Methods in Enzymol.) 上撰写英文专著1章。

代表性著作：

  1. Zhang, P. #, Meng, S. #, Li, Z. #,Hirtz, D., Elling, L., Zhu, L.,Ji, Y. *, Schwaneberg, U.*, A Comparative Molecular Dynamics Approach Guides the Tailoring of Glycosyltransferases to Meet Synthetic Applications, Green Chemistry, 2024, doi.org/10.1039/D4GC01508H.

  2. Dong, Z., Zhang, P., Slavko, K., Ji, Y.*, Schwaneberg, U.*,Synergism of endo and exo-α-1,3-glucanases in α-1,3-glucan degradation: a kinetic study, ACS Sustainable Chemistry & Engineering, 2024, 12, 24, 9123-9132 (Cover).

  3. Zhi, Z. #,*, Ji, Y. #, Schwaneberg, U.*, Advances in Sortase-Mediated Ligation: Leveraging the Power of Directed Evolution and Beyond, Angewandte Chemie International Edition, 2024, e202310910.

  4. Feng, L., Gao, L., Besirlioglu, V., Essani, K., Kurkina, T., Ji, Y.*, Schwaneberg, U.*, FACS based ultrahigh-throughput screening methodology for the directed evolution of oxidases, Angewandte Chemie International Edition, 2023,62, e202214999.

  5. Lu, Y., Hintzen, K., Kurkina, K., Ji, Y.*, Schwaneberg, U.*, Directed evolution of material binding peptide for polylactic acid-specific degradation in mixed plastic wastes, ACS Catalysis, 2023, 13, 19, 12746-12754 (Cover).

  6. Li, Z.#, Meng, S.#, Nie, K., Schwaneberg, U., Davari, M., Ji, Y.*, Liu, L.*, Flexibility reduction of loops surrounding the tunnel entrance in cytochrome P450 enhanced substrate access substantially, ACS Catalysis, 2022, 12, 12800-12808(Cover).

  7. Lu, Y., Hintzen, K., Kurkina, K., Ji, Y.*, Schwaneberg, U.*, A Competitive High‐Throughput Screening Platform for Designing Polylactic Acid‐Specific Binding Peptides, Advanced Science, 2023,10, 2303195.

  8. Meng, S.#, Li, Z.#, Ji, Y.#, *, Ruff, A., Davari M.*, Schwaneberg, U.*, Introduction of aromatic amino acids in electron transfer pathways yielded improved catalytic performance of cytochrome P450s, Chinese Journal of Catalysis, 2023, 49, 81-90.

  9. Zhang, P., Ji, Y.*, Meng, S., Li, Z., Hirtz, D., Elling, L., Schwaneberg, U.*, Phylogeny-based Directed Evolution Strategy Promote Efficient Catalysis of Novel Glycosyltransferases toward Bottleneck Substrates, Green Chemistry, 2023, 25, 8108 - 8116.

  10. Meng, S.#, Li, Z.#, Zhang, P., Contreras, F., Ji, Y.*, Schwaneberg, U.*, Deep learning guided enzyme engineering of Thermobifida fusca cutinase for increased PET degradation, Chinese Journal of Catalysis, 2023, 50, 229-238.

  11. Han, R., Gao, K., Zhou, J., Xu, G., Dong, J., Schwaneberg, U., Ji, Y.*, Ni, Y.*, A Self-Sufficient in vitro Multi-Enzyme Cascade for Efficient Synthesis of Danshensu from L-DOPA, ACS Synthetic Biology, 2023, 12, 1, 277-286.

  12. Meng, S.#, Ji, Y.#,*, Dhoke, G., Davari, M.*, Schwaneberg, U.*, The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s, Biotechnology Advances, 2022, 108051.

  13. Meng, S.#, Ji, Y.#, Davari, M., Liu, L., Schwaneberg, U.*, Modulating the coupling efficiency of P450 BM3 by controlling water diffusion through access tunnel engineering, ChemSusChem, 2022, 15(9), e202102434.

  14. Umair, M., Jabeen, S., Ke, Z., Jabbar, S., Javed, F., Abid, M., Khan, K., Ji, Y.*, Kormai, S., Saadony, M., Zhao, L.*, Cacciotti, I., Lima, C., Conte-Junior, C., Thermal treatment alternatives for enzymes inactivation in fruit juices: Recent breakthroughs and advancements,Ultrasonics Sonochemistry, 2022,105999.

  15. Ji, Y., Lu, Y.,Pütz, H., Schwaneberg U.*, Anchor peptides promote degradation of mixed plastics for recycling, Methods in Enzymology, 2021, 648, 271-292. (Book chapter)

  16. Ji, Y., Islam, S., Cui, H., Dhoke, G., Davari, M., Mertens, M., Schwaneberg U.*, Loop engineering of aryl sulfotransferase B for improving catalytic performance in regioselective sulfation, Catalysis Science & Technology, 2020, 10, 2369-2377.

  17. Ji, Y., Islam, S., Mertens, M., Sauer D., Dhoke, G., Jakob F., Schwaneberg, U.*, Directed aryl sulfotransferase evolution toward improved sulfation stoichiometry on the example of catechols, Applied Microbiology and Biotechnology, 2019, 1-11.

  18. Ji, Y., Mertens, M., Gertler C., Fekiri, S., Keser M., Sauer D., Smith K., Schwaneberg, U.*, Directed OmniChange Evolution Converts P450 BM3 into an Alkyltrimethylammonium Hydroxylase, Chemistry - A European Journal, 2018, 24(63): 16865-16872.


教师寄语:

一分耕耘，一分收获。


招生要求：

善于思考，乐观开朗。