姓名：季宇 职称：教授 邮箱：yuji@mail.buct.edu.cn 办公地址：高精尖大厦801 |
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教育背景：
2008.09-2012.07 北京化工大学 应用化学 学士
2012.09-2015.06 北京化工大学 化学 硕士
2015.09-2020.05 德国亚琛工业大学 生物技术 博士
工作经历：
2020.01–2020.05 德国亚琛工业大学生物技术研究所，博士后
2020.05–2024.05 德国亚琛工业大学生物技术研究所，研究组组长
2023.05-2024.05 德国SeSaM生物技术公司，首席科学家（兼职）
2024.06–2025.11 北京化工大学生命科学与技术学院，副教授
2025.12-至今 北京化工大学生命科学与技术学院，教授
主要研究领域：
蛋白质工程，酶催化
学术兼职：
Bioresources and Bioprocessing期刊客座编辑，德国生物经济科学中心(BioSC)成员
学术成绩：
入选国家级青年人才，主持国家自然科学基金项目2 项，国家重点研发计划课题、子课题各1项，曾负责/参与欧盟委员会（EU）项目、德国德国科学基金会（DFG）、德国联邦教育与研究部（BMBF）项目8项，参与中石油创新基金等项目。
发表SCI论文50余篇，其中以第一/通讯作者在Chem，Angew. Chem.，Int. Ed.，ACS Catal.，Adv. Sci.，Green Chem.等期刊发表论文30余篇, 并应邀在国际知名丛书：酶学方法 (Methods in Enzymol.)上撰写英文专著1章。
代表性著作：
2026
[1] Li, X., Ji, Y.*, Li, G., Meng, S., Zhang, P., Liu, Y., Ding, E., Sun, K., Tan, T. *, Schwaneberg, U.*, Mimicking a solvent interface at the substrate access channel of nylonase accelerates nylon degradation,Green Chemistry, 2026, 28 (3), 1722-1733
[2] Meng, S., Ji, Y.*, Yew, M., Zhu, L., Schwaneberg, U.*, Lessons learned on how to reengineer enzymes for improved performance in ionic liquids: insights from BSLA saturation mutagenesis library, Green Chemistry, DOI: 10.1039/D5GC04809E.
2025
[1] Lu, Y., Bourdeaux, F., Nian B., Manimaran, P, Verma B., Rommerskirchen M., Bold, S., Zhu, L., Ji, Y.*, Schleifenbaum, J., Schwaneberg, U.*, Engineered material binding peptide empowers biocatalysis in stainless steel flow reactors for phosphate recovery, 2025, Chem, 11,102395.
[2] Zhang, P #, Dong, Z. #, Meng, S., Li, Z., Ji, Y.*, Schwaneberg, U.*, Anchor Peptide-based Immobilization Strategy Promote the Applications of Pickering Emulsion System in Glycosylation, Angewandte Chemie International Edition, 2025, e202500834.
[3] Meng, S., Li, Z., Zhang, P., Ji, Y.*, Schwaneberg, U.*, Capturing intrinsic protein dynamics for explaining beneficial substitutions from protein engineering campaigns, Biotechnology Advances, 2025, 108660.
[4] Li, Z., Meng, S., Ji, Y.*, Zhang, P., Nian, B., Zhu, C., Davari, M., Xu, H., Schwaneberg, U. *, Liu, L. *, Global dynamic design (GDD) empowers cytochrome P450s for improved catalytic performance,ACS Sustainable Chemistry & Engineering,2025, 13 (10), 3834-3841.
[5] Sun, C., Li, Z.*, Ji, Y.*, Schwaneberg, U., Li, Z.*, CMDmpnn: Combining comparative molecular dynamics and ProteinMPNN to rapidly expand enzyme substrate spectrum，Journal of Chemical Information and Modeling, 2025, 65 (6), 2741-2747.
2024
[1] Zhi, Z.#,*, Ji, Y.#, Schwaneberg, U.*, Advances in Sortase-Mediated Ligation: Leveraging the Power of Directed Evolution and Beyond, Angewandte Chemie International Edition, 2024, e202310910.
[2] Zhang, P. #, Meng, S. #, Li, Z. #, Hirtz, D., Elling, L., Zhu, L., Ji, Y. *, Schwaneberg, U.*, A Comparative Molecular Dynamics Approach Guides the Tailoring of Glycosyltransferases to Meet Synthetic Applications, Green Chemistry, 2024, 26 (16), 9186-9194.
[3] Dong, Z., Zhang, P., Slavko, K., Ji, Y.*, Schwaneberg, U.*, Synergism of endo and exo-α-1,3-glucanases in α-1,3-glucan degradation: a kinetic study, ACS Sustainable Chemistry & Engineering, 2024, 12, 24, 9123-9132 (Cover).
2023
[1] Feng, L., Gao, L., Besirlioglu, V., Essani, K., Kurkina, T., Ji, Y.*, Schwaneberg, U.*, FACS based ultrahigh-throughput screening methodology for the directed evolution of oxidases, Angewandte Chemie International Edition, 2023, e202214999.
[2] Lu, Y., Hintzen, K., Kurkina, K., Ji, Y.*, Schwaneberg, U.*, Directed evolution of material binding peptide for polylactic acid-specific degradation in mixed plastic wastes, ACS Catalysis, 2023, 13, 19, 12746-12754 (Cover).
[3] Lu, Y., Hintzen, K., Kurkina, K., Ji, Y.*, Schwaneberg, U.*, A Competitive High‐Throughput Screening Platform for Designing Polylactic Acid‐Specific Binding Peptides, Advanced Science, 2023,10, 2303195.
[4] Meng, S.#, Li, Z.#, Ji, Y.#, *, Ruff, A., Davari M.*, Schwaneberg, U.*, Introduction of aromatic amino acids in electron transfer pathways yielded improved catalytic performance of cytochrome P450s, Chinese Journal of Catalysis, 2023, 49, 81-90.
[5] Meng, S.#, Li, Z.#, Zhang, P., Contreras, F., Ji, Y.*, Schwaneberg, U.*, Deep learning guided enzyme engineering of Thermobifida fusca cutinase for increased PET degradation, Chinese Journal of Catalysis, 2023, 50, 229-238.
[6] Zhang, P., Ji, Y.*, Meng, S., Li, Z., Hirtz, D., Elling, L., Schwaneberg, U.*, Phylogeny-based Directed Evolution Strategy Promote Efficient Catalysis of Novel Glycosyltransferases toward Bottleneck Substrates, Green Chemistry, 2023, 25, 8108 - 8116.
[7] Han, R., Gao, K., Zhou, J., Xu, G., Dong, J., Schwaneberg, U., Ji, Y.*, Ni, Y.*, A Self-Sufficient in vitro Multi-Enzyme Cascade for Efficient Synthesis of Danshensu from L-DOPA, ACS Synthetic Biology, 2023, 12, 1, 277-286.
2022
[1] Li, Z.#, Meng, S.#, Nie, K., Schwaneberg, U., Davari, M., Ji, Y.*, Liu, L.*, Flexibility reduction of loops surrounding the tunnel entrance in cytochrome P450 enhanced substrate access substantially, ACS Catalysis, 2022, 12, 12800-12808(Cover).
[2] Meng, S.#, Ji, Y.#,*, Dhoke, G., Davari, M.*, Schwaneberg, U.*, The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s, Biotechnology Advances, 2022, 108051.
[3] Meng, S.#, Ji, Y.#, Davari, M., Liu, L., Schwaneberg, U.*, Modulating the coupling efficiency of P450 BM3 by controlling water diffusion through access tunnel engineering, ChemSusChem, 2022, 15(9), e202102434.
教师寄语:
一分耕耘，一分收获。
招生要求：
善于思考，乐观开朗，执行力强。
