史硕博

史硕博

教育背景：

2000.9–2004.7,   河北工业大学   生物工程 学士

2004.9–2009.9   天津大学   生物化工 博士

工作经历：

2009.11 -2012.12     瑞典查尔姆斯理工大学，博士后

2013.1 -2017.8       新加坡科技研究局, 科学家

2017.8  - 今        北京化工大学, 见习教授，教授

主要研究领域：

代谢工程和合成生物学

学术兼职：

BioDesign Research，BMC Biotechnology，Frontiers in Bioengineering and Biotechnology, Synthetic Biology and Engineering等英文期刊编辑和《合成生物学》期刊编辑；国家自然科学基金委、科技部国家重点研发计划和北京市自然科学基金委评审专家。

学术成绩：

教授，博士生导师。主要从事代谢工程与合成生物学的研究工作，构建和改造微生物使其能够直接用于高效生产有用的生物燃料或化学品，开发优化CRISPR基因组编辑工具在菌株构建以及体外检测等领域的应用。先后主持包括国家自然科学基金面上项目在内的国家级及省部级基金10余项；申请发明专利9项、授权3项；以第一/通讯作者在Nat. Commun.、Metab. Eng.和Trends Biotechnol.等期刊发表SCI文章60余篇（包括2篇ESI高被引论文）。

代表性著作：

1.  Genlai Dong, Ying Zhao, Wentao Ding, Shijie Xu, Qi Zhang, Huimin Zhao*, Shuobo Shi*. (2024) Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids. Metabolic Engineering, 82: 100

2.  Qun Yue#, Jie Meng#, Yue Qiu, Miaomiao Yin, Liwen Zhang, Weiping Zhou, Zhiqiang An, Zihe Liu, Qipeng Yuan, Wentao Sun, Chun Li, István Molnár*, Yuquan Xu*, Shuobo Shi* (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nature Communications, 14: 4267. (Highlighted and featured by Editor as one of the 50 best papers recently published in "Biotechnology and methods" area).

3.  Jinyu Fu, Linghao Zhang, Yanlin Long, Zihe Liu, Geng Meng, Huimin Zhao, Xin Su*, Shuobo Shi*. (2023) Multiplexed CRISPR-based nucleic acid detection using a single Cas protein. Analytical Chemistry, 95: 16089–16097

4.  Genlai Dong, Shijie Xu, Shuobo Shi* (2023) De novo biosynthesis of free vaccenic acid with a low content of oleic acid in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 71: 16204–16211

5.  Nailing Qi, Wentao Ding, Genlai Dong, Zhihui Wang, Shuobo Shi* (2023) De novo bio-production of odd-chain fatty acids in Saccharomyces cerevisiae through a synthetic pathway via 3-hydroxypropionic acid. Biotechnology and Bioengineering. 120: 852-858.

6.  Jie Meng, Yue Qiu, Yueping Zhang, Huimin Zhao, Shuobo Shi* (2023) CMI: CRISPR/Cas9 based efficient multiplexed integration in Saccharomyces cerevisiae. ACS Synthetic Biology. 12: 1408

7.  Weibo Qiao, Shijie Xu, Zihe Liu, Xiaoying Fu, Huimin Zhao, Shuobo Shi* (2022). Challenges and opportunities in C1-based biomanufacturing. Bioresource Technology, 364: 128095

8.  Wentao Ding, Qiongyu Meng, Genlai Dong, NailingQi, Huimin Zhao*, Shuobo Shi* (2022) Metabolic engineering of threonine catabolism enables Saccharomyces cerevisiae to produce propionate under aerobic conditions. Biotechnology Journal, 17:2100579. (ESI Highly Cited Papers)

9. Shuobo Shi, Zhihui Wang, Lirong Shen, Han Xiao (2022) Synthetic biology: pushing the new frontier of food production. Trends in Biotechnology. 40: 781.

10.  Yang Zhang, Jie Peng, Huimin Zhao, Shuobo Shi* (2021) Engineering oleaginous yeast Rhodotorula toruloides for overproduction of fatty acid ethyl esters. Biotechnology for Biofuels, 14:115.

教师寄语:

勇敢追求梦想，勤奋拼搏未来。

招生要求：

善于观察，勤于思考，勇于实践。