范爱丽

发布时间:2019-10-31

 

姓名:范爱丽

 

职称:副教授

 

邮箱:fanal@mail.buct.edu.cn

 

办公地址:科技大厦西配楼514


教育背景:

2011.9-2015.8  德国马尔堡大学药学系,博士(药学与生物技术专业)

2005.9-2011.7  北京大学药学院,学士硕士(药学专业)


工作经历:

2017.9-至今    北京化工大学生命科学与技术学院,副教授,硕士生导师

2015.10-2017.8  中国科学院微生物研究所,助理研究员


学术兼职:


主要研究领域:

1. 真菌次级代谢产物的生物合成及调控

2. 真菌次级代谢产物合成途径中关键酶的鉴定及催化机制研究

3. 利用合成生物学技术进行低劣生物质的无害化与资源化


科研项目:

2019/01-2021/12,国家自然科学基金青年科学基金项目,表观遗传调控哈茨木霉中“沉默”化合物的激活及活性评价,在研,主持

2019/01-2023/12,国家自然科学基金-重点基金,在研,参加


代表性著作:

1) Li, W. #, Fan, A.(Fan, Aili)#, Wang, L., Zhang, P., Liu, Z., An, Z., Yin, W.-B. (2018) Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem. Sci. 9, 2589-2594. (# contribute equally)
2) Fan, A.#, Mi, W. #, Liu, Z., Zeng, G., Zhang, P., Hu, Y., Fang, W., Yin, W.-B. (2017) Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii. Org. Lett. 19,1686-1689. 
3) Fan, A. and Li, S.-M. (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides. Appl. Microbiol. Biotechnol. 100, 5389-5399.
4) Fan, A. and Li, S.-M. (2013). One substrate - seven products with different prenylation positions in one-step reactions: prenyltransferases make it possible. Adv. Synth. Catal. 355, 2659-2666.
5) Fan, A., Zocher, G., Stec, E., Stehle, T., and Li, S.-M. (2015). Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. J. Biol. Chem. 290, 1364-1373.
6) Fan, A., Winkelblech, J. and Li, S.-M. (2015). Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Appl. Microbiol. Biotechnol. 99, 7399-7415. (invited review).
7) Fan, A., Xie, X. and Li, S.-M. (2015). Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Org. & Biomol. Chem. 13, 7551-7557.
8) Fan, A. and Li, S.-M. (2014). Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahedron Lett. 55, 5199-5202.
9) Fan, A., Chen, H., Wu, R., Xu, H., and Li, S.-M. (2014). A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Appl. Microbiol. Biotechnol. 98, 10119-10129.
10) Fan, A., Lin, W., and Jia, Y. (2011) Recent research progress in the research on lamellarins and related pyrrole-derived alkaloids from marine organisms. J. Chin. Pharm. Sci. 20, 425–441. (Invited review)

教师寄语:

“进一寸有一寸的欢喜”


招生要求:

乐观善良、踏实努力、执行力强、有一定的自学能力