刘子鹤

发布时间:2019-10-31

姓名:刘子鹤

 

职称:副教授

 

邮箱:zihe@mail.buct.edu.cn

 

办公地址:综合楼配楼104

 


教育背景:

2002.9-2006.6 天津大学化工学院,学士(生物工程专业)

2006.9-2008.6 天津大学化工学院,硕士(生物化工专业 导师:赵学明教授)

2008.9-2012.11瑞典查尔摩斯大学,博士(系统及合成生物学专业 导师:Jens Nielsen 教授)


工作经历:

2013.1-2017.8:新加坡科技研究局 科学家I

2017.9-至今:北京化工大学科学与技术学院 副教授

2019. 1-至今:北京化工大学科学与技术学院生物工程系主任


学术兼职:


主要研究领域:

实验室主要研究方向为代谢工程、系统生物学、合成生物学,具体包括:

1. 细胞机理

2. 细胞工厂

3. 系统与合成生物学工具的开发


获奖及荣誉:

2019.7 北京化工大学青年英才百人计划


科研项目:

2018.1    北京市自然科学基金面上项目   主持

2019.7    国家重点研发计划“合成生物学” 重点专项 课题负责人

2019.7    国家重点研发计划“合成生物学” 重点专项 子课题负责人


代表性著作:

1.    Zhang Y, Wang J, Wang Z, Zhang Y, Shi S, Nielsen J, Liu Z#. A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae. Nature Commun., 2019, 10(1): 1053. (IF=11.878)

2.    Liu Z, Zhang Y, Nielsen J#. Synthetic biology of yeast. Biochemistry, 2019, 58(11), 1511-1520. (IF=2.952)

3.    Zhang Y, Nielsen J, Liu Z#. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived hydrocarbons. Biotechnol. Bioeng., 2018, 11(9), 2139-2147. (IF=4.26)

4.    Zhang Y, Nielsen J, Liu Z#. Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels. FEMS Yeast Res., 2017, 17 (8), fox080 (IF=2.458)

5.    Liu Z, Liang Y, Ang EL#, Zhao H#. The New Era of Genome Integration – Simply Cut and Paste! ACS Syn. Biol., 2017, 6, 601−609. (IF=5.571)

6.    Liang J*, Liu Z*, Ang EL#, Zhao H#.  Twin-primer non-enzymatic DNA assembly: an efficient and accurate multi-part DNA assembly method. 2017. Nucleic Acids Res., 45 (11): e94. (IF=11.147)

7.    Sun H*, Liu Z*, Zhao H, Ang EL#. Recent advances in combinatorial biosynthesis for drug discovery. Drug Des. Dev. Ther., 2015, 9:823—833. *Equal contribution. (IF=3.208)

8.    Liu Z, Liu L, Österlund T, Hou J, Huang M, Fagerberg L, Petranovic D, Uhlén M, Nielsen J#. Improved production of a heterologous amylase in yeast by inverse metabolic engineering. Appl. Environ. Microbiol., 2014, 80(17):5542-5550. (IF=4.077)

9.    Liu Z, Österlund T, Hou J, Petranovic D, Nielsen J#. Anaerobic α-Amylase production and secretion with fumarate as the final electron acceptor in Saccharomyces cerevisiae. 2013.  Appl. Environ. Microbiol., 79(9): 2962-2967. (IF=4.077)

10.  Liu Z, Hou J, Martínez JL, Petranovic D, Nielsen J#. Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae. 2013. Appl. Microbiol. Biotechnol., 97(20): 8955-8962. (IF=3.67)

11.  Liu Z, Tyo KE, Martínez JL, Petranovic D, Nielsen J#. Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. 2012. Biotechnol. Bioeng., 109(5): 1259-1268. (IF=4.26)

12.  Hou J*, Tyo KE*, Liu Z*, Petranovic D, Nielsen J#. Metabolic engineering of recombinant protein production by Saccharomyces cerevisiae. 2012. FEMS Yeast Res, 12(5): 491-510. *Equal contribution. (IF=2.458)


教师寄语:

“As a scientist, you must constantly question yourself, your experiment and your data to find out what you might have overlooked, why the experiment did not work or why the results contradict you initial assumptions.”

Leonardo Almeida-Souza & Jonathan Baets


招生要求:

独立思考、勤奋好学、重诺守信