姓名：李灏 职称：副教授 邮箱：lihao@mail.buct.edu.cn |  |
教育背景：
1995.9-1999.6 山东大学生命学院，理学学士（微生物学专业）
1999.9-2002.6 山东大学生命学院，理学硕士（微生物学专业）
2002.9-2005.6 中国海洋大学海洋生命学院，理学博士（海洋生物学专业）
工作经历：
2005.8-2008.10 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，博士后研究工作
2008.12-至今 北京化工大学生命科学与技术学院，副教授
学术兼职：
主要研究领域：
1.微生物学（微生物胁迫耐受性、微生物菌间互作等）。
2.适配体的筛选、优化及应用（筛选、优化、检测新策略的构建；构建基于适配体的传感器，用于临床标志物诊断、食品残留药物检测及环境污染物监测等）。
3.系统生物学及其应用。
获奖及荣誉：
2018年 北京化工大学十佳教师
科研项目：
近5年来，作为项目主持人，承担了国家自然科学基金1项，国家“863”重大项目子课题1项，中科院B类专项协作课题1项，福建省海洋高新产业发展专项项目1项，山东省自主创新及成果转化专项1项，国家重点实验室开放基金2项以及企业委托课题1项等。
代表性著作：
1) Yujing Ding, Zihan Gao, Hao Li*. Real milk sample assisted selection of specific aptamer towards sarafloxacin and its application in establishment of an effective aptasensor. Sensors and Actuators B: Chemical, 2021, 343: 130113. (*通讯作者) (TOP杂志)
2) Xin Kang, Zihan Gao, Lingjie Zheng, Xiaoru Zhang, Hao Li*. Regulation of Lactobacillus plantarum on the reactive oxygen species related metabolisms of Saccharomyces cerevisiae. LWT-Food Science and Technology, 2021, 147, 111492.(*通讯作者) (TOP杂志)
3) Zihan Gao, Xiaoyan Du, Yujing Ding, Hao Li*. Establishment of a dual-aptasensor for simultaneous detection of chloramphenicol and kanamycin. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 2021, DOI: 10.1080/19440049.2021.1914871. (*通讯作者)
4) Xianlin He, Bo Liu, Yali Xu, Ze Chen, Hao Li*. Effects of Lactobacillus plantarum on the ethanol tolerance of Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 2021, 105(6), 2597-2611. DOI: 10.1007/s00253-021-11198-x. (*通讯作者) (TOP杂志)
5) Hongwei Hu, Yujing Ding, Zihan Gao, Hao Li*. S1 nuclease digestion-based rational truncation of PD-L1 aptamer and establishment of a signal dual amplification aptasensor.Sensors and Actuators B: Chemical, 2021, 331: 129442. (*通讯作者) (TOP杂志)
6) Xiaoru Zhang, Yaxian Zhang, Zhihua Ji, Fengbang Wang, Lei Zhang, Maoyong Song*, Hao Li*. Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A. Environmental Toxicology and Pharmacology, 2020, 80: 103507. (*通讯作者)
7) Yujing Ding, Yuanpu Niu, Ze Chen, Shijun Dong, Hao Li*. Discovery of novel Lactobacillus plantarum co-existence-associated influencing factor(s) on Saccharomyces cerevisiae fermentation performance. LWT-Food Science and Technology, 2020, 135: 110268. (*通讯作者) (TOP杂志)
8) Xiaoru Zhang, Yaxian Zhang, Hao Li*. Regulation of trehalose, a typical stress protectant, on central metabolisms, cell growth and division of Saccharomyces cerevisiae CEN.PK113-7D. Food Microbiology, 2020, 89: 103459. (*通讯作者) (TOP杂志)
9) Chuchu Wang, Xiaoyan Du, Tiantian Xie, Hao Li*. Label- and modification-free-based in situ selection of bovine serum albumin specific aptamer. Journal of Separation Science, 2019, 42 (23): 3571-3578. (*通讯作者)
10) Ming Li, Hongwei Hu, Ze Chen, Yaxian Zhang, Hao Li*. Using drug-loaded pH-responsive poly(4-vinylpyridine) microspheres as a new strategy for intelligent controlling of Lactobacillus plantarum contamination in bioethanol fermentation. World Journal of Microbiology and Biotechnology, 2018, 34 (10): 146. (*通讯作者)
11) Ze Chen, Zhou Zheng, Fenglian Wang, Yuanpu Niu, Jinlai Miao*, Hao Li*. Intracellular metabolic changes of Rhodococcus sp. LH during the biodegradation of diesel oil. Marine Biotechnology, 2018, 20 (6): 803-812. (*通讯作者) (TOP杂志)
12) Zhihua Ji, Yaxian Zhang, Juan Tian, Fengbang Wang, Maoyong Song*, Hao Li*. Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells. Ecotoxicology and Environmental Safety, 2018, 161: 1-7. (*通讯作者) (TOP杂志)
13) Lihui Wang, Chuchu Wang, Hao Li*. Selection of DNA aptamers and establishment of an effective aptasensor for highly sensitive detection of cefquinome residues in milk. Analyst, 2018, 143: 3202-3208. (*通讯作者)
14) Juan Tian, Zhihua Ji, Fengbang Wang, Maoyong Song*, Hao Li*. The toxic effects of Tetrachlorobisphenol A in Saccharomyces cerevisiae cells via metabolic interference. Scientific Reports, 2017, 7 (1): 2655. (*通讯作者)
15) Ye Duan, Lihui Wang, Zhiqiang Gao, Huishan Wang, Hexiao Zhang*, Hao Li*. An aptamer-based effective method for highly sensitive detection of chloramphenicol residues in animal-sourced food using real-time fluorescent quantitative PCR. Talanta, 2017, 165: 671-676. (*通讯作者) (TOP杂志)
16) Bo Liu,Huaqing Liu, Yunxiao Zhang, Hao Li*. Control of Lactobacillus plantarum contamination in bioethanol fermentation by adding plantaricins. International Journal of Agriculture and Biology, 2017, 19: 171-176. (*通讯作者)
17) Juan Tian, Shuxian Zhang, Hao Li*. Changes in intracellular metabolisms underlying the adaptation of Saccharomyces cerevisiae strains to ethanol stress. Annals of Microbiology, 2017, 67 (2): 195-202. (*通讯作者)
18) Ze Chen, Zhou Zheng, Chenfeng Yi, Fenglian Wang, Yuanpu Niu, Hao Li*.Intracellular metabolic changes of Saccharomyces cerevisiaeand promotion to ethanol tolerance during the bioethanol fermentation process. RSC Advances, 2016, 6: 105046-105055. (*通讯作者)
19) Yuanpu Niu, Xianghua Lin, Shijun Dong, Qipeng Yuan, Hao Li*. Indentation with atomic force microscope,Saccharomyces cerevisiae cell gains elasticity under ethanol stress. The International Journal of Biochemistry & Cell Biology, 2016, 79: 337-344. (*通讯作者)
20) Yanfeng Wang, Juan Tian, Zhihua Ji, Maoyong Song, Hao Li*. Intracellular metabolic changes of Clostridium acetobutylicum and promotion to butanol tolerance during biobutanol fermentation. The International Journal of Biochemistry & Cell Biology, 2016, 78: 297-306. (*通讯作者)
21) Ye Duan, Zhiqiang Gao, Lihui Wang, Huishan Wang, Hexiao Zhang*, Hao Li*. Selection and identification of chloramphenicol specific DNA aptamers by Mag-SELEX. Applied Biochemistry and Biotechnology, 2016, 180 (8): 1644-1656. (*通讯作者)
22) Chenfeng Yi, Fenglian Wang, Shijun Dong, Hao Li*. Changes of trehalose content and expression of relative genes during the bioethanol fermentation by Saccharomyces cerevisiae. Canadian Journal of Microbiology, 2016, 62 (10): 827-835. (*通讯作者)
23) Shijun Dong, Chenfeng Yi, Hao Li*. Changes of Saccharomyces cerevisiae cell membrane components and promotion to ethanol tolerance during the bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 69: 196-203. (*通讯作者)
24) Shijun Dong, Xianghua Lin, Hao Li*. Regulation of Lactobacillus plantarum contamination on the carbohydrate and energy related metabolisms of Saccharomyces cerevisiae during bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 68: 33-41. (*通讯作者)
25) XiangPei HanShijun DongHao Li*.Preparation and application of bacteriophage-loaded chitosan microspheres for controlling Lactobacillus plantarum contamination in bioethanol fermentation. RSC Advances, 2015, 5: 69886-69893. (*通讯作者)
26) Yanfeng Wang, Shuxian Zhang, Huaqing Liu, Lei Zhang, Chenfeng Yi, Hao Li*. Changes and roles of membrane compositions in the adaptation of Saccharomyces cerevisiae to ethanol.Journal of Basic Microbiology, 2015, 55 (12): 1417-1426. (*通讯作者)
27) Fengxia Cui, Ruimin Zhang, Huaqing Liu, Yanfeng Wang, Hao Li*. Metabolic responses to Lactobacillus plantarum contamination or bacteriophage treatment in Saccharomyces cerevisiae using a GC-MS-based metabolomics approach. World Journal of Microbiology & Biotechnology, 2015, 31 (12): 2003-2013.(*通讯作者)
28) Fengxia Cui, Huaqing Liu, Zhongmei Zou*, Hao Li*. Metabolic responses to water deprivation in C57BL/6J mice using a proton nuclear magnetic resonance-based metabonomics approach. RSC Advances, 2015, 5: 80142-80149. (*通讯作者)
29) Ribang Wu, CuiLing Wu, Dan Liu, Xinghao Yang, Jiafeng Huang, Jiang Zhang, Binqiang Liao, Hailun He*, Hao Li*. Overview of antioxidant peptides derived from marine resources: the sources, characteristic, purification, and evaluation methods. Applied Biochemistry and Biotechnology, 2015,176 (7): 1815-1833. (*通讯作者)
30) Dan Liu, Xinghao Yang, Jiafeng Huang, Ribang Wu, Cuiling Wu, Hailun He*, Hao Li*. In situ demonstration and characteristic analysis of the protease components from marine bacteria using substrate immersing zymography. Applied Biochemistry and Biotechnology, 2015, 175 (1): 489-501. (*通讯作者)
31) Manli Ma, Pei Han, Ruimin Zhang, Hao Li*. Ultrastructural changes of Saccharomyces cerevisiae in response to ethanol stress. Canadian Journal of Microbiology, 2013, 59 (9): 589-597. (*通讯作者)
32) 段烨, 高志强, 王慧珊, 张鹤晓, 李灏*. 核酸适体技术及其在兽药残留检测中的应用. 中国兽医杂志, 2015, 51 (11): 75-78. (*通讯作者)
33) 方华, 李灏*. 海藻糖与热激蛋白在酿酒酵母耐受乙醇胁迫中的作用, 中国生物工程杂志, 2014, 34（6）: 84-89. (*通讯作者)
34) 刘华擎, 李灏*. 生物质能源发酵中染菌及防控的研究进展, 中国生物工程杂志, 2013, 33 (12): 114-120. (*通讯作者)
35) Xianmei Hu, Hao Li*, Pingwah Tang, Jie Sun, Qipeng Yuan, Chunfang Li. GC-MS-based metabolomics study of the responses to arachidonic acid in Blakeslea trispora. Fungal Genetics and Biology, 2013, 57: 33-41. (*共同第一作者)
36) Hao Li, Manli Ma, Sha Luo, Ruimin Zhang, Pei Han, Wei Hu. Metabolic responses to ethanol in Saccharomyces cerevisiae using a gas chromatography tandem spectrometry-based metabolomics approach. The International Journal of Biochemistry & Cell Biology, 2012, 44 (7): 1087-1096.
37) Hao Li, Manli Ma, Huijun Xie, Jian Kong. Biosafety evaluation of bacteriophages for treatment of diarrhea due to intestinal pathogen Escherichia coli 3-2 infection of chickens. World Journal of Microbiology and Biotechnology, 2012, 28: 1-6.
38) Hao Li, Lan Wang, Xianzhong Yan, Qijun Liu, Chaohui Yu, Handong Wei, Youming Li, Xuemin Zhang, Fuchu He, Ying Jiang. A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. Journal of Proteome Research, 2011, 10 (6): 2797-2806.
39) Zijun He, Shizeng Wang, Yumeng Yang, Jing Hu, Can Wang, Hao Li, Bokai Ma, Qipeng Yuan. β-Carotene production promoted by ethylene in Blakeslea trispora and the mechanism involved in metabolic responses. Process Biochemistry, 2017, 57: 57-63.
40) Ming Yang, Meng Ren, Yue Qu, Wendi Teng, Zhongpeng Wang, Hao Li, Qipeng Yuan. Sulforaphene inhibits hepatocellular carcinoma through repressing keratin 8 and activating anoikis. RSC Advances, 2016, 6 (74): 70326-70334.
41) Ge Wang, Zehao Li, Hao Li, LidanLi, Jian Li, Changyuan Yu. Metabolic profile changes of CCl4-liver fibrosis and inhibitory effects of Jiaqi Ganxian granule. Molecules, 2016, 21 (6). pii: E698.
42) Jing Hu, Hao Li, Yumeng Yang, Shizeng Wang, Pingwah Tang, Chunfang Li, Guifang Tian, Qipeng Yuan. Metabolic regulation of α-linolenic acid on β-carotene synthesis in Blakeslea trispora revealed by a GC-MS-based metabolomic approach. RSC Advances, 2015, 5 (78): 63193-63201.
43) Shizeng Wang, Hao Li, Xiaoguang Fan, Jingkun Zhang, Pingwah Tang, Qipeng Yuan. Metabolic responses in Candida tropicalis to complex inhibitors during xylitol bioconversion. Fungal Genetics and Biology, 2015, 82: 1-8.
44) 李灏, 刘华擎, 王砚凤, 李思越. 酿酒酵母分泌表达 plantaricin A抑制植物乳杆菌的方法. 专利授权号: ZL 2015 1 0366397.0（授权公告日2018.05.01）
45) 李灏, 李明, 陈泽, 张雅娴. 一种基于药物缓、控释的载药微球防控生物乙醇发酵染菌的方法. 专利授权号：ZL 2017 1 1371899.8（授权公告日2021.02.19）
教师寄语:
在兴趣中探索，在探索中收货。
招生要求：
动手能力强，思维活跃，视野开阔。